Centre for Stem Cell Research
A unit of inStem, Bengaluru, Christian Medical College Capmus, Bagayam Vellore
- Elizabeth Vinod, Ganesh Parasuraman, , Solomon Sathishkumar, Boopalan Ramasamy. Isolation of Articular Cartilage Resident Cells Chondrocytes, Fibronectin Adhesion Assay Derived and Migratory Chondroprogenitors. Journal of Visualized Experiments: Biology, Oct 4th 2024. https://app.jove.com/t/67160/isolation-chondrocytes-chondroprogenitors-using-fibronectin-adhesion
- Babu Chandraprabha, P., Thangavel, S. Endocytosis as a critical regulator of hematopoietic stem cell fate-implications for hematopoietic stem cell and gene therapy. Stem Cell Res Ther 15, 319 (2024). https://doi.org/10.1186/s13287-024-03927-6.
- Porkizhi A, Durga K, Mahalingam G, Ashish K Goel, Uday Z, Alok S, Srujan M*, Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders. Acta Pharmaceutica Sinica B. Volume 14, Issue 7, July 2024, Pages 2885-2900.
- Elizabeth Vinod, Ganesh Parasuraman, Soosai Manickam Amirtham, Sandya Rani, Abel Livingston, Solomon Sathishkumar. Enhanced Visualization of Articular Cartilage Chondroprogenitor-Derived Extracellular Vesicles Using Cytospin Centrifugation for Confocal Imaging. European Journal of Anatomy. Volume: 28 Number: 4 July 2024.
- Ganesh Parasuraman, Soosai Manickam Amirtham, Deepak Vinod Francis, Abel Livingston, Boopalan Ramasamy, Solomon Sathishkumar, Elizabeth Vinod. Evaluation of Chondral Defect Repair Using Human Fibronectin Adhesion Assay derived chondroprogenitors suspended in Lyophilized Fetal Collagen Scaffold: An Ex Vivo Osteochondral Unit Model Study. Indian Journal of Orthopaedics. May 2024. https://link.springer.com/article/10.1007/s43465-024-01192-6
- John Solomon, VS Kalaiselvi, MK Kalaivani, Juwain Shehzad Nehil, WMS Johnson, Chitraleka SaiKumar, Christhunesa Soundararajan Christudass, Sandya Rani. T-cell Response after COVID-19 Vaccination: A Cross-sectional Study. Journal of Clinical and Diagnostic Research. 2024 Feb, Vol-18(2): DC01-DC06. https://doi.org/10.7860/JCDR/2024/66884.18997.
- Benjamin ESB, Vinod E, Illangeswaran RSS, Rajamani BM, Vidhyadharan RT, Bagchi A, Maity A, Mohan A, Parasuraman G, Amirtham SM, Abraham A, Velayudhan SR, Balasubramanian P. Immortalised chronic myeloid leukemia (CML) derived mesenchymal stromal cells (MSCs) line retains the immunomodulatory and chemoprotective properties of CML patient-derived MSCs. Cell Signal. 2024 Jan 27;116:111067. doi: 10.1016/j.cellsig.2024.111067. Online ahead of print. PMID: 38281615.
- Rajendiran V, Devaraju N, Haddad M, Ravi NS, Panigrahi L, Paul J, Gopalakrishnan C, Wyman S, Ariudainambi K, Mahalingam G, Periyasami Y, Prasad K, George A, Sukumaran D, Gopinathan S, Pai AA, Nakamura Y, Balasubramanian P, Ramalingam R, Thangavel S, Velayudhan SR, Corn JE, Mackay JP, Marepally S, Srivastava A, Crossley M, Mohankumar KM. Base editing of key residues in the BCL11A-XL-specific zinc finger domains de-represses fetal globin expression. Mol Ther. 2024 Jan 24:S1525-0016(24)00023-6. doi: 10.1016/j.ymthe.2024.01.023. Epub ahead of print. PMID: 38273654.
- Altaf MT, Kandagaddala M, Selina A, Madhuri V. J. Perthes-Like Disorder in a Child with Atypical Bohring-Opitz Syndrome. BJS Case Connect. 2024 Jan 5;14(1). doi: 10.2106/JBJS.CC.23.00433. eCollection 2024 Jan 1. PMID: 38181165.
- Amirtham, S. M., Parasuraman, G., Lisha, J., Francis, D. V., Livingston, A., Rebekah, G., & Vinod, E. . Decellularized fetal collagen exhibits chondroinductive potential for bone marrow-derived mesenchymal stem cells by enhancing glycosaminoglycan production. European Journal of Anatomy, 28(1), 13-23, (2024). doi: 10.52083/kjjc3228
- Arjunan, P., Kathirvelu, D., Mahalingam, G., Goel, A. K., Zacharaiah, U. G., Srivastava, A., & Marepally, S. Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders. Acta Pharmaceutica Sinica B (2024). doi: 10.1016/j.apsb.2024.04.015
- Biswas, D., Mahalingam, G., Subaschandrabose, R. K., Priya, S., Ramachandran, R., Suresh, S., Moorthy, M.. Role of prior immunity in binding to spike of “future” Omicron subvariants. Indian Journal of Medical Microbiology, 50, 100615 (2024). doi: 10.1016/j.ijmmb.2024.100615.
- Ijee, S., Chambayil, K., Chaudhury, A. D., Bagchi, A., Modak, K., Das, S., Velayudhan, S. R. Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs. Frontiers in molecular biosciences, 10, 1295507-1295507 (2024). doi: 10.3389/fmolb.2023.1295507.
- J, J. L., Parasuraman, G., Amirtham, S. M., Francis, D. V., Livingston, A., Goyal, A., Vinod, E. Comparative assessment of chondral defect repair using migratory chondroprogenitors suspended in either gelled or freeze-dried platelet-rich plasma: An in vitro and ex vivo human osteochondral unit model study. The Knee, 48, 105-119 (2024). doi: 10.1016/j.knee.2024.03.006
- Jebanesan, D. Z. P., Illangeswaran, R. S. S., Rajamani, B. M., Vidhyadharan, R. T., Das, S., Bijukumar, N. K., Balasubramanian, P. Inhibition of NRF2 signaling overcomes acquired resistance to arsenic trioxide in FLT3-mutated Acute Myeloid Leukemia. Annals of Hematology, 103(6), 1919-1929 (2024). doi: 10.1007/s00277-024-05742-8
- Mahalingam, G., & Marepally, S. In a quest for bivalent mRNA vaccine for respiratory viruses: An effective strategy to overcome antigenic competition. Molecular Therapy, 32(4), 873-874 (2024). doi: 10.1016/j.ymthe.2024.03.011
- Mahalingam, G., Rachamalla, H. K., Arjunan, P., Karuppusamy, K. V., Periyasami, Y., Mohan, A., Marepally, S. SMART-lipid nanoparticles enabled mRNA vaccine elicits cross-reactive humoral responses against the omicron sub-variants. Molecular therapy : the journal of the American Society of Gene Therapy, 32(5), 1284-1297 (2024). doi: 10.1016/j.ymthe.2024.02.028.
- Melenshia, D. S., Amirtham, S. M., Rebekah, G., Vinod, E., & Kachroo, U. Effect of reconstituted, lyophilized cold aqueous extract of Aloe vera on human whole blood clotting time - A pilot study. Journal of Ayurveda and Integrative Medicine, 15 (2), 100887-100887 (2024). doi: 10.1016/j.jaim.2024.100887.
- Prasad, K., Devaraju, N., George, A., Ravi, N. S., Paul, J., Mahalingam, G., Mohankumar, K. M. Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors. Molecular therapy. Nucleic acids, 35(2), 102205-102205 (2024). doi: 10.1016/j.omtn.2024.102205.
- Krittika Nandy, Dinesh Babu, Sonam Rani, Gaurav Joshi, Smitha Ijee, Anila George, Dhavapriya Palani, Chitra Premkumar, Praveena Rajesh, S. Vijayanand, Ernest David, Mohankumar Murugesan & Shaji R. Velayudhan. Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Sci Rep 13, 21953 (2023). https://doi.org/10.1038/s41598-023-42174-2.
- Ravi NS, George A, Mohankumar KM. Protocol for arrayed gRNA screening by base editors in mammalian cell lines using lentiviral system. STAR Protoc. 2023 Nov 2;4(4):102668. doi: 10.1016/j.xpro.2023.102668. Epub ahead of print. PMID: 37922314.
- Elizabeth Vinod, Ganesh Parasuraman, Abel Livingston, Soosai Manickam Amirtham, Grace Rebekah, Jeya Lisha J, Alfred Job Daniel, Solomon Sathishkumar. Comparison of methods for the isolation and culture of Migratory Chondroprogenitors from Human articular cartilage. . Connect Tissue Res . 2023 Jul;64(4):389-399.
- Agnes Selina. Deeptiman James, Vrisha Madhuri. A Novel Biallelic Splice Site Variant in the SPARC Gene Causing Severe Osteogenesis Imperfecta. Indian J Pediatr . 2023 Jun;90(6):626.
- Raina K, Joshi G, Modak K, Premkumar C, Priyanka S, Rajesh P, Velayudhan SR,Thummer RP. Generation and characterization of induced pluripotent stem cell line IITGi001-A derived from adult human primary dermal fibroblasts. Stem Cell Res. 2023 Jun 28;71:103159. doi: 10.1016/j.scr.2023.103159.
- Rani, S., Thamodaran, V., Nandy, K., Fouzia, N. A., Maddali, M., Rajesh, P., Velayudhan, S. R. Establishment and characterization of CSCRi006-A: an induced pluripotent stem cell line generated from a patient with Diamond-Blackfan Anemia (DBA) carrying ribosomal protein S19 (RPS19) mutation. Human Cell, 36(6), 2204-2213 (2023). doi: 10.1007/s13577-023-00946-y
- Esther Sathya Bama Benjamin, Dinesh Babu, Gaurav Joshi, Bharathi M Rajamani, Krittika Nandy, Sonam Rani, Senthamizhselvi Anandan, Chitra Premkumar, Madhavi Maddali, Aby Abraham, Shaji R Velayudhan, Poonkuzhali Balasubramanian. Inhibition of BCR::ABL1 tyrosine kinase activity Aids in the Generation of Stable Chronic Myeloid Leukemia Induced Pluripotent Stem Cells. bioRxiv 2023.06.01.543015; doi: https://doi.org/10.1101/2023.06.01.543015 .
- Gokulnath M, Porkizhi A, Yogapriya P, Ajay D, Nivedita D, Vignesh R, Abhisha C, Ramya Devi KT2, Immanuel D, Saravanabhavan T, Mohankumar M, Mahesh M, Alok S, Srujan M, Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor. Scientific Reports 2023 May30.13(1):8743.
- Elizabeth Vinod, Jeya Lisha J, Ganesh Parasuraman, Abel Livingston, Alfred Job Daniel, Solomon Sathishkumar. Evaluation of Ghrelin as a distinguishing marker for human articular cartilage-derived chondrocytes and chondroprogenitors. Journal of Clinical Orthopaedics and Trauma. 2023 May 29;41:102175.
- Rajamani BM, Illangeswaran RSS, Benjamin ESB, Balakrishnan B, Jebanesan DZP, Das S, Pai AA, Vidhyadharan RT, Mohan A, Karathedath S, Abraham A, Mathews V, Velayudhan SR, Balasubramanian P. Modulating retinoid-X-receptor alpha (RXRA)expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo. Front Pharmacol. 2023 May 31;14:1187066.
- Alok Srivastava, Savita Rangarajan, Kaan Kavakli, Robert Klamrot, Gili Kenet, Liane Khoo, Chur-Woo You, Weiqun Xu , Niel Malan, Laurent Frenzel, Catherine N Bagot, Oleksandra Stasyshyn, Chia-Yau Chang, Stacey Poloskey, Zhiying Qiu, Shauna Andersson, Baisong Mei and Steven W Pipe . Fitusiran prophylaxis in people with severe haemophilia A or haemophilia B without inhibitors (ATLAS-A/B): a multicentre, open-label, randomised, phase 3 trial. Lancet Haematol . 2023 May;10(5):e322-e332. DOI:https://doi.org/10.1016/S2352-3026(23)00037-6.
- George, A., Ravi, N. S., Vaishnavi, B., Marepally, S., Thangavel, S., Velayudhan, S. R., .Mohankumar, K. M. (2023). Editing of highly homologous gamma-globin genes by nickase deficient Base Editor mitigates large intergenic deletions: Cold Spring Harbor Laboratory. bioRxiv 2023.12.04.569931; doi: https://doi.org/10.1101/2023.12.04.569931
- Elizabeth Vinod, Ganesh Parasuraman, Jeya Lisha J, Soosai Manickam Amirtham, Abel Livingston, Jithu James Varghese, Sandya Rani, Deepak Vinod Francis, Grace Rebekah, Alfred Job Daniel, Boopalan Ramasamy, Solomon Sathishkumar. Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells. PLoS One . 2023 Apr 27;18(4):e0285106.
- Venkatesan V, Christopher AC, Rhiel M, Azhagiri MKK, Babu P, Walavalkar K, Saravanan B, Andrieux G, Rangaraj S, Srinivasan S, Karuppusamy KV, Jacob A, Bagchi A, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Pai R, Marepally SK, Mohankumar KM, Velayudhan SR, Boerries M, Notani D, Cathomen T, Srivastava A, Thangavel S. Editing the core region in HPFH deletions alters fetal and adult globin expression for the treatment of β-hemoglobinopathies. Mol Ther Nucleic Acids. 2023 Apr 26;32:671-688. doi: 10.1016/j.omtn.2023.04.024. PMID: 37215154; PMCID: PMC10197010.
- Guy Young, Alok Srivastava, Kaan Kavakli, Cecil Ross, Jameela Sathar, Chur-Woo You, Huyen Tran, Jing Sun, Runhui Wu, Stacey Poloskey, Zhiying Qiu, Salim Kichou, Shauna Andersson, Baisong Mei, Savita Rangarajan. Efficacy and safety of fitusiran prophylaxis in people with haemophilia A or haemophilia B with inhibitors (ATLAS-INH): a multicentre, open-label, randomised phase 3 trial. Lancet . 2023 Apr 29;401(10386):1427-1437. DOI:https://doi.org/10.1016/S0140-6736(23)00284-2.
- Raveen Stephen, Stallon Illangeswaran, Daniel Zechariah Paul Jebanesan , Kezia Kanimozhi Sivakumar , Rakhi Thalayattu Vidhyadharan , Bharathi M. Rajamani , Nancy Beryl Janet , Ernest David , Shaji Ramachandran Velayudhan, Vikram Mathews , Poonkuzhali Balasubramanian. Chemotherapeutic drugs elicit stemness and metabolic alteration to mediate acquired drug-resistant phenotype in acute myeloid leukemia cell lines. Leukemia Research, Volume 128, May 2023. (https://www.sciencedirect.com/science/article/abs/pii/S0145212623000395?via%3Dihub)
- Gaurav Joshi, Nancy Bery, Janet Arthur , Thenral S Geetha , Phaneendra Venkateswara Rao Datari , Kirti Modak , Debanjan Roy , Anurag Dutta Chaudhury , Prasanth Sundaraganesan , Sweety Priyanka , Fouzia Na , Vedam Ramprasad , Aby Abraham , Vivi M Srivastava , Alok Srivastava , Uday Prakash Kulkarni , Biju George , Shaji R Velayudhan. Comprehensive laboratory diagnosis of Fanconi anaemia: comparison of cellular and molecular analysis. J Med Genet. 2023 Mar 9; jmedgenet-2022-108714. doi: 10.1136/jmg-2022-108714. Online ahead of print.
- Hemalatha R, Muthuraman N, Sandya Rani, Premila Abraham. A study on the alteration of endoplasmic reticulum stress related proteins in cyclophosphamide induced damage to urothelium. Pharmaceutical and Biomedical research on 31.01.2023.
- Lohchania B, Christopher A, Arjunan P, Mahalingam G, Kathirvelu D, Prasannan A, Venkatesan V, Taneja P, Mohan Kumar Km , Thangavel S , Marepally S ."Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways. Front Bioeng Biotechnol. 2023 Jan 9;10:1031049. doi: 10.3389/fbioe.2022.1031049.
- Mahalingam G, Periyasami Y, Arjunan P, Subaschandrabose RK, Mathivanan TV, Mathew RS, Ramya Devi K, Premkumar PS, Muliyil J, Srivastava A, Moorthy M*, Marepally S*. Omicron infection increases IgG binding to spike protein of predecessor variants. J Med Virol . 2023 Feb;95(2):e28419. doi: 10.1002/jmv.28419.
- Francis, D. V., Rajeswari, A. J., Stephen, J. B., Parasuraman, G., Lisha J, J., Livingston, A.,Vinod, E. An ultrastructural report of human articular cartilage resident cells in correlation with their phenotypic characteristics. Journal of Histotechnology, 47(1), 23-38, 2023. doi: 10.1080/01478885.2023.2278118.
- Murugesan, R., Karuppusamy, K. V., Marepally, S., & Thangavel, S. (2023). Current approaches and potential challenges in the delivery of gene editing cargos into hematopoietic stem and progenitor cells. Frontiers in genome editing, 5, 1148693-1148693. doi: 10.3389/fgeed.2023.1148693.
- Parasuraman, G., Vinod, E., Livingston, A., Sathishkumar, S., & Francis, D. V. Comparative assessment of the morphology and antigenicity of human osteochondral units using formalin and coagulant fixatives. European Journal of Anatomy, 705-716, 2023. doi: 10.52083/cvzf3774.
- George A, Ravi NS, Prasad K, Panigrahi L, Koikkara S, Rajendiran V, Devaraju N, Paul J, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, Mohankumar KM. Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2, Front Genome Ed. 2022 Dec 20;4:1085111. doi: 10.3389/fgeed.2022.1085111
- Venkatesan V, Christopher A, Karuppusamy K, Babu P, Azhagiri M and Thangavel S. CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications. JoVE. August 9, 2022 doi: 10.3791/64064
- Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, de Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, di Rocco M, Delai PLR, Diecidue RJ, Madhuri V, Cho TJ, Morhart R, Friedman CS, Zasloff M, Pals G, Shim JH, Gao G, Kaplan F, Pignolo RJ, Micha D. Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles. Hum Gene Ther. 2022 Aug;33(15-16):782-788.
- Rapaka H, Manturthi S, Arjunan P, Venkatesan V, Thangavel S, Marepally S, Patri S V. Influence of Hydrophobicity in the Hydrophilic Region of Cationic Lipids on Enhancing Nucleic Acid Delivery and Gene Editing. ACS Appl bio Mater (2022) 5:1489–1500
- Chilbule SK, Rajagopal K, Walter N, Dutt V, Madhuri V. Role of WNT Agonists, BMP and VEGF Antagonists in Rescuing Osteoarthritic Knee Cartilage in a Rat Model. Indian J Orthop. 2022;56(1):24–33.
- Franklyn J, Ramesh S, Madhuri V, Patel B, Dhivya A, Nair PD, et al. Abdominal Wall Reconstruction with Tissue-Engineered Mesh Using Muscle-Derived Stem Cells in an Animal Model. Regenerative Engineering and Translational Medicine (2022).
- James D, Subramanian L, Selina A, Palocaren T, Madhuri V. Novel TRPV4 Pathogenic Variant in Severe Metatropic Skeletal Dysplasia: A Case Report. Malays Orthop J. 2022 Jul;16(2):145-149.
- Jehangir S, Ramesh S, Thomas M, Madhuri V. Wharton’s Jelly Mesenchymal Stem Cells on a Novel Aloe Vera-Polycaprolactone (A-PCL) Composite Scaffold in Burns. Regenerative Engineering and Translational Medicine (2022) (1).
- Reiss UM, Mahlangu J, Ohmori T, Ozelo MC, Srivastava A, Zhang L. Haemophilia gene therapy-Update on new country initiatives. Haemophilia. 2022 May;28 Suppl 4:61-67. doi: 10.1111/hae.14512. PMID: 35521726.
- Cuende N, Ciccocioppo R, Forte M, Galipeau J, Ikonomou L, Levine BL, Srivastava A, Zettler PJ. Patient access to and ethical considerations of the application of the European Union hospital exemption rule for advanced therapy medicinal products. Cytotherapy. 2022 Jul;24(7):686-690. doi: 10.1016/j.jcyt.2022.03.007. Epub 2022 May 8. PMID: 35545453.
- Christopher AC, Venkatesan V, Karuppusamy KV, Srinivasan S, Babu P, Azhagiri MKK, Chambayil K, Bagchi A, Rajendiran V, Ravi NS, Kumar S, Marepally SK, Mohankumar KM, Srivastava A, Velayudhan SR, Thangavel S. Preferential Expansion of Human CD34+CD133+CD90+ Hematopoietic Stem Cells Enhances Gene-Modified Cell Frequency for Gene Therapy. Hum Gene Ther. 2022 Feb;33(3-4):188-201. doi: 10.1089/hum.2021.089. Epub 2022 Jan 7. PMID: 34486377.
- Singh G, Manian KV, Premkumar C, Srivastava A, Daniel D, Velayudhan SR. Derivation of Clinical-Grade Induced Pluripotent Stem Cell Lines from Erythroid Progenitor Cells in Xenofree Conditions. Methods Mol Biol. 2022; 2454:775-789. doi: 10.1007/7651_2021_349. PMID: 33950379.
- Thamodaran V, Rani S, Velayudhan SR. Gene Editing in Human Induced Pluripotent Stem Cells Using Doxycycline-Inducible CRISPR-Cas9 System. Methods Mol Biol. 2022; 2454:755-773. doi: 10.1007/7651_2021_348. PMID: 33830454.
- Prasad K, Devaraju N, George A, Ravi NS, Mahalingam G, … Mohankumar KM* et al. Precise modelling and correction of a spectrum of β-thalassemic mutations in human erythroid cells by base editors [Internet]. bioRxiv; 2022 [cited 2022 Jun 13]. p. 2022.06.01.494256.(biorxiv preprint)
- Tejram Sahu*, Srujan Marepally*, Rajeev Tyagi* Editorial: Nanomedicine in infectious diseases: Drug delivery and vaccines Frontiers in Pharmacology, Front Pharmacol. 2022 Aug 17;13:928572.
- Rapaka H, Manturthi S, Gosangi M, Lohchania B, Marepally S*, Patri SV*. Effect of Methylation of the Hydrophilic Domain of Tocopheryl Ammonium-Based Lipids on their Nucleic Acid Delivery Properties. ACS Omega. 2022 7(18):15396-15403. doi:10.1021/acsomega. 1c06889.
- Hari Krishnareddy Rachamalla, Chandrashekhar Voshavar, Porkizhi arjunan, Gokulnath Mahalingam, Rashmi Praksash Chowath, Rajkumar Banerjee*, Praveen Kumar Vemula*, Srujan Marepally* Skin permeable nano-lithocholic-lipidoid efficiently alleviates psoriasis-like chronic skin inflammations. ACS Applied Materials and Interfaces, 2022, 14(13):14859-14870.
- Abhirup Bagchi, Nivedhitha Devaraju, Karthik Chambayil, Vignesh Rajendiran, Vigneshwaran Venkatesan, Nilofer Sayed, Aswin Anand Pai, Aneesha Nath, Ernest David, Yukio Nakamura, Poonkuzhali Balasubramanian, Alok Srivastava, Saravanabhavan Thangavel, Kumarasamypet M. Mohankumar & Shaji R. Velayudhan. Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications. Scientific Reports volume 12, Article number: 14033 (2022).
- Das S, Stallon Illangeswaran RS, Ijee S, Kumar S, Velayudhan SR, Balasubramanian P. Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype. J Vis Exp. 2022 Jun 17;(184). doi: 10.3791/63383. PMID: 35786700.
- Vigneshwaran Venkatesan, Abisha Crystal Christopher, Prathibha Babu, Manoj Kumar K Azhagiri, Kaivalya Walavalkar, Bharath Saravanan, Saranya Srinivasan, Karthik V Karuppusamy, Annlin Jacob, Sumathi Rangaraj, Abhirup Bagchi, Aswin Anand Pai, Yukio Nakamura, Poonkuzhali Balasubramanian, Rekha Pai, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Shaji R Velayudhan, Dimple Notani, Alok Srivastava, Saravanabhavan Thangavel. Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies. DOI:https://doi.org/10.1101/2022.07.11.499646
- Hubert D-J Daniel, Sanjay Kumar, Rajesh Kannangai, Farzana J, Joseph N Joel, Aby Abraham, Kavitha M Lakshmi, Mavis Agbandje-McKenna, Kirsten E Coleman, Arun Srivastava, Alok Srivastava, Asha M Abraham. Age-stratified adeno-associated virus serotype 3 neutralizing and total antibody prevalence in hemophilia A patient from India. Journal of Medical Virology 2022 May 16. Online ahead of print. PMID: 35577570 DOI: 10.1002/jmv.27859
- Devaraju N, Rajendiran V, Ravi NS, Mohankumar KM. Genome Engineering of Hematopoietic Stem Cells Using CRISPR/Cas9 System. Methods Mol Biol. 2022;2429:307-331. doi: 10.1007/978-1-0716-1979-7_20. PMID: 35507170
- Precilla S , Kuduvalli S , Praveena E , Thangavel S and T S Anitha. Integration of synthetic and natural derivatives revives the therapeutic potential of temozolomide against glioma- an in vitro and in vivo perspective. Life Sci. 2022 May 6; 301:120609. doi: 10.1016/j.lfs.2022.120609.
- Mahalingam G, Rachamalla HK, Arjunan P, Periyasami Y, M S, Thangavel S, Mohankumar KM, Moorthy M, Velayudhan SR, Srivastava A, Marepally S. Optimization of SARS-CoV-2 Pseudovirion Production in Lentivirus Backbone With a Novel Liposomal System. Front Pharmacol. 2022 Mar 25;13:840727. doi: 10.3389/fphar.2022.840727. PMID: 35401169; PMCID: PMC8990231.
- Noel Naveen Johnson, Soosai Manickam Amirtham, B. Sandya Rani, Solomon Sathishkumar, Grace Rebekah, and Elizabeth Vinod. Assessment of the inherent chondrogenic potential of human articular cartilage-derived chondroprogenitors in pellet culture using a novel whole pellet processing approach. Journal of Orthopaedics, March 2022. https://doi.org/10.1016/j.jor.2022.03.007.
- Karuppusamy K, Demosthenes J, Venkatesan V, Christopher A, Babu P, Azhagiri M, Jacob A, Ramalingam V, Rangaraj S, Mohankumar K.M, Marepally S, Varghese G, Srivastava A, Kannangai R and Thangavel S. The CCR5 gene-edited CD34+CD90+ Hematopoietic stem cell population serves as an optimal graft source for HIV gene therapy. Front. Immunol., 14 March 2022.
- Ravi NS, Wienert B, Wyman SK, Bell HW, George A, Mahalingam G, Vu JT, Prasad K, Bandlamudi BP, Devaraju N, Rajendiran V, Syedbasha N, Pai AA, Nakamura Y, Kurita R, Narayanasamy M, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, DeWitt MA, Crossley M, Corn JE, Mohankumar KM.. Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. Elife. 2022 Feb 11;11:e65421. doi: 10.7554/eLife.65421. PMID: 35147495; PMCID: PMC8865852.
- Sowmya Ramesh, Farasat Zaman, Lars Sävendahl, Vrisha Madhuri. Radial Shockwave Treatment Promotes Chondrogenesis in Human Growth Plate and Longitudinal Bone Growth in Rabbits. Bone Volume 154, January 2022, 116186.
- Elizabeth Vinod, Noel Naveen Johnson, Sanjay Kumar, Soosai Manickam Amirtham, Jithu Varghese James, Abel Livingston, Grace Rebekah, Alfred Job Daniel, Boopalan Ramasamy and Solomon Sathishkumar. Migratory chondroprogenitors retain superior intrinsic chondrogenic potential for regenerative cartilage repair as compared to human fibronectin derived chondroprogenitors. Scientific reports. November 2021. https://doi.org/10.1038/s41598-021-03082-5.
- Elizabeth Vinod, Kawin Padmaja, Abel Livingston, Jithu Varghese James, Soosai Manickam Amirtham, Solomon Sathishkumar, Boopalan Ramasamy, Grace Rebekah, Alfred Job Daniel, UpasanaKachroo. Prospective isolation and characterization of chondroprogenitors from human chondrocytes based on CD166/CD34/CD146 surface markers. CARTILAGE. September 2021. doi:10.1177/19476035211042412.
- Manoj Kumar K. Azhagiri, Prathibha Babu, Vigneshwaran Venkatesan & Saravanabhavan Thangavel. Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapy. Stem Cell Research & Therapy. 12; 500 (2021). https://doi.org/10.1186/s13287-021-02565-6.
- Abisha Crystal Christopher, Vigneshwaran Venkatesan, Karthik V Karuppusamy, Saranya Srinivasan, Prathibha Babu, Manoj Kumar K Azhagiri, Karthik C, Abhirup Bagchi, Vignesh Rajendiran, Nithin Sam Ravi, Sanjay Kumar, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Alok Srivastava, Shaji R Velayudhan, Saravanabhavan Thangavel. Preferential expansion of human CD34+CD133+CD90+ hematopoietic stem cells enhances gene-modified cell frequency for gene therapy. Hum Gene Ther. 2021 Sep 5. doi: 10.1089/hum.2021.089. Online ahead of print.
- Roshni Parameswaran, Upasana Kachroo, Soosai Manickam Amirtham, Grace Rebekah, Elizabeth Vinod. An invitro analysis of the effect of hyperosmolarity on the chondrogenic potential of human articular cartilage derived chondroprogenitors. Tissue and Cell. Volume 72, October 2021, 101590.
- Jannu AK, Puppala ER, Gawali B, Syamprasad NP, Alexander A, Marepally S, Chella N, Gangasani JK, Naidu VGM. Lithocholic acid-tryptophan conjugate (UniPR126) based mixed micelle as a nano carrier for specific delivery of niclosamide to prostate cancer via EphA2 receptor. J Pharm. 2021 Jun 22;605: 120819. doi: 10.1016/j.ijpharm.2021.120819.
- Soosai Manickam Amirtham, Upasana Kachroo, Deepak Vinod Francis, Kawin Padmaja and Elizabeth Vinod. An improved method for processing chondroprogenitor pellets following chondrogenic differentiation for histology and immunohistochemical staining using agarose. Journal of Arthroscopy and Joint Surgery Available online 29 May 2021.
- Sanjay K. Chilbule, Karthikeyan Rajagopal, Noel Walter, Vivek Dutt & Vrisha Madhuri. Role of WNT Agonists, BMP and VEGF Antagonists in Rescuing Osteoarthritic Knee Cartilage in a Rat Model. Indian Journal of Orthopaedics (2021)
- Vrisha Madhuri, Sowmya Ramesh, Renita Raymond, Agnes Selina and Lakshmi Loganathan. Translational Research in Osteogenesis Imperfecta and Cell Therapy (Conference Report). Proceedings 2021, 72(1), 3; 10 May 2021.
- Sowmya Ramesh, Dolly Daniel, Cecilia Götherström, Vrisha Madhuri. Trophic effects of multiple administration of mesenchymalstem cells in children with osteogenesis imperfecta. Clinical and Translational Medicine, 2021;11:e385.
- Elizabeth Vinod, Soosai Manickam Amirtham, Upasana Kachroo, Anjali Goyal, Ozlem Ozbey, Jithu Varghese James, Solomon Sathishkumar, Boopalan Ramasamy. Articular chondroprogenitors in platelet rich plasma for treatment of osteoarthritis and osteochondral defects in a rabbit knee model. The Knee. 13th April 2021.
- Karthik V Karuppusamy , Prathibha Babu , Saravanabhavan Thangavel. The Strategies and Challenges of CCR5 Gene Editing in Hematopoietic Stem and Progenitor Cells for the Treatment of HIV. Stem Cell Rev Rep. 31st March 2021[PMID: 33788143 DOI: 10.1007/s12015-021-10145-7].
- Elizabeth Vinodab, Soosai Manickam Amirthama, Upasana Kachroo. An assessment of bone marrow mesenchymal stem cell and human articular cartilage derived chondroprogenitor cocultures vs. monocultures. The Knee Volume 29, March 2021, Pages 418-425.
- Abhirup Bagchi, Aneesha Nath, Vasanth Thamodaran, Smitha Ijee, Dhavapriya Palani, Vignesh Rajendiran, Vigneshwaran Venkatesan, Phaneendra Datari, Aswin Anand Pai, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Yukio Nakamura, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, Saravanabhavan Thangavel and Shaji R. Velayudhan. Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells. Cells 2021, 10, 523. https://doi.org/ 10.3390/cells10030523.
- Vigneshwaran Venkatesan, Saranya Srinivasan, Prathibha Babu and Saravanabhavan Thangavel. Manipulation of Developmental Gamma-Globin Gene Expression: an Approach for Healing Hemoglobinopathies. Molecular and cellular biology, Jan., 2021. DOI: 10.1128/MCB.00253-20.
- Vrisha Madhuri, Agnes Selina, Lakshmi Loganathan, Ashis Kumar, Vignesh Kumar, Renita Raymond, Sowmya Ramesh, Nimmy Vincy, Giftson Joel, Deeptiman James, Madhavi Kandagaddala, Antonisamy B. Osteogenesis imperfecta: Novel genetic variants and clinical observations from a clinical exome study of 54 Indian patients. Ann Hum Genet . 2021 Jan;85(1):37-46.
- Karthikeyan Rajagopal, Sowmya Ramesh, Noel Malcolm Walter, Aditya Arora, Dhirendra S. Katti, and Vrisha Madhuri. In vivo cartilage regeneration in a multi-layered articular cartilage architecture mimicking scaffold. Bone Joint Res. 2020 Sep; 9(9): 601–612.
- Elizabeth Vinod, Upasana Kachroo, Grace Rebekah, Bijesh Kumar Yadav and Boopalan Ramasamy. Characterization of human articular chondrocytes and chondroprogenitors derived from non-diseased and osteoarthritic knee joints to assess superiority for cell-based therapy. Acta Histochemica Volume 122, Issue 6, September 2020, 151588.
- Elizabeth Vinod, Roshni Parameswaran, Boopalan Ramasamy and Upasana Kachroo. Pondering the Potential of Hyaline Cartilage-Derived Chondroprogenitors for Tissue Regeneration: A Systematic Review. Cartilage . 2020 Aug 25;1947603520951631. doi: 10.1177/1947603520951631.
- Sowmya Ramesh, Lars Sävendahl, Vrisha Madhuri, Farasat Zaman. Radial shock waves prevent growth retardation caused by the clinically used drug vismodegib in ex vivo cultured bones. Sci Rep . 2020 Aug 7;10(1):13400. doi: 10.1038/s41598-020-69904-0.
- Harrison C. Brown, Christopher B. Doering, Roland W. Herzog, Chen Ling, David M. Markusic, H. Trent Spencer, Alok Srivastava, and Arun Srivastava. Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B. Human Gene Therapy. 2020 Aug 17. doi: 10.1089/hum.2020.099.
- Upasana Kachroo, Elizabeth Vinoda. Comparative analysis of gene expression between articular cartilage-derived cells to assess suitability of fibronectin adhesion assay to enrich chondroprogenitors. The Knee Volume 27, Issue 3, June 2020, Pages 755-759.
- Elizabeth Vinod, Roshni Parameswaran, Soosai Manickam Amirtham, Abel Livingston, Boopalan Ramasamy,Upasana Kachroo. Comparison of the efficiency of laminin versus fibronectin as a differential adhesion assay for isolation of human articular cartilage derived chondroprogenitors.Connective Tissue Research (14th May 2020). doi: 10.1080/03008207.2020.1761344. [Epub ahead of print].
- Upasana Kachroo, Shikha Mary Zachariah, Augustine Thambaiah, Aleya Tabasum, Abel Livingston, Grace Rebekah, Alok Srivastava and Elizabeth Vinod. Comparison of human platelet lysate versus fetal bovine serum for expansion of human articular cartilage derived chondroprogenitorsCartilage (14th May 2020) 2020. doi: 10.1177/1947603520918635. [Epub ahead of print].
- Upasana Kachroo, Boopalan Ramasamy, Elizabeth Vinod. Evaluation of CD49e as a distinguishing marker for human articular cartilage derived chondroprogenitors. Knee. 2020 Apr 18. pii: S0968-0160(20)30077-6. doi: 10.1016/j.knee.2020.04.002. [Epub ahead of print].
- Elizabeth Vinod, Tephilla Epsibha Jefferson, Soosai Manickam Amirtham, Neetu Prince, Tulasi Geevar, Grace Rebekah, Boopalan Ramasamy, Upasana KachrooCorrelation between synovial fluid calcium containing crystal estimation and varying grades of Osteoarthritis using a rabbit model: Potential diagnostic toolJournal of Clinical Orthopaedics and Trauma. (07thApril2020)https://doi.org/10.1016/j.jcot.2020.03.031
- Elizabeth Vinod, Boopalan Ramasamy,Upasana Kachroo.Comparison of immunogenic markers of human chondrocytes and chondroprogenitors derived from non-diseased and osteoarthritic articular cartilage.Journal of Orthopaedics, Trauma and Rehabilitation (03rd April 2020). https://doi.org/10.1177/2210491720915927
- Rajagopal K, Ramesh S, Madhuri V. Early Addition of Parathyroid Hormone-Related Peptide Regulates the Hypertrophic Differentiation of Mesenchymal Stem Cells. Cartilage. 2020 Jan 2:1947603519894727. doi: 10.1177/1947603519894727.
- Amirtham SM, Ozbey O, Kachroo U, Ramasamy B, Vinod E. Optimization of Immunohistochemical Detection of Collagen Type II in Osteochondral Sections by Comparing Decalcification and Antigen Retrieval Agent Combinations. Clinical Anatomy, Volume 33, Issue 3, April 2020 Pages 343-349.
- Madhuri, Vrisha; Ramesh, Sowmya; Varma, Harikrishna; Sivadasan, Suresh Babu; Sahoo, Bibhudatta; John, Annie; Fernandez, Francis; Rajagopal, Karthikeyan; Mathews, Vikram; Balakumar, B; Dinesh, Vivek Dutt; Chilbule, Sanjay Kashinath; Gibikote, Sridhar; Srivastava, Alok. First Report of a Tissue-Engineered Graft for Proximal Humerus Gap Non-union After Chronic Pyogenic Osteomyelitis in a Child. The Journal of Bone and Joint Surgery, Incorporated – Case Connector: January-March 2020 – Volume 10 – Issue 1 – p e0031 doi: 10.2106/JBJS.CC.19.00031a.
- Ramesh S, Zaman F, Madhuri V, Sävendahl L. Radial Extracorporeal Shock Wave Treatment Promotes Bone Growth and Chondrogenesis in Cultured Fetal Rat Metatarsal Bones. Clin Orthop Relat Res . 2020 Mar;478(3):668-678.
- Vinod E, Kachroo U, Amirtham SM, Ramasamy B, Sathishkumar S. Comparative analysis of fresh chondrocytes, cultured chondrocytes and chondroprogenitors derived from human articular cartilage. Acta Histochemica Volume 122, Issue 1, January 2020, 151462.
- Jeyanth Suresh Rose, Sharmili Lalgudi, Aarwin Joshua, Joshua Paul, Augustine Thambaiah, Syrpailyne Wankhar, Geeta Chacko, Thomas Kuriakose, Sanita Korah. An experimental study to test the efficacy of Mesenchymal Stem Cells in reducing corneal scarring in an ex-vivo organ culture model. Exp Eye Res . 2020 Jan;190, 107891.
- N Sharma, AK Dhyani, S Marepally, AJ Devadoss. Nanoscale lipid vesicles functionalized with nitro-aniline derivative for photoinduced nitric oxide (NO) delivery. Nanoscale Advances, 2020, 2, 463.
Book Chapters
- C Voshavar, PK Vemula, S Marepally. Topical and Transdermal Delivery with Chemical Enhancers and Nanoparticles, 2020.Imaging Technologies and Transdermal Delivery in Skin Disorders, 169-200. Publisher: John Wiley & Sons, Ltd
- Ramalingam S, Thangavel S. CRISPR-Cas9 Probing of Infectious Diseases and Genetic Disorders. Indian J Pediatr. 2019 Dec;86(12):1131-1135.
- Vinod E, Ozbey O, Sabareeswaran A, Kachroo U, Sathishkumar S, Boopalan PRJVC. Comparison of monosodium iodoacetate model of osteoarthritis between in-vivo and ex-vivo osteochondral unit in rabbits. J Clin Orthop Trauma. 2019 Oct;10(Suppl 1):S1-S2.
- Vinod E, Francis D, Jacob T, Amirtham SM, Sathishkumar S, Kanthakumar P, Oommen V. Autologous platelet rich fibrin as a scaffold for chondrocyte culture and transplantation: An in vitro bovine study. J Clin Orthop Trauma. 2019 Oct;10(Suppl 1):S26-S31.
- Elizabeth Vinoda, Jithu Varghese James, Upasana Kachroo, Solomon Sathishkumar, Abel Livingstond, Boopalan Ramasamy. Comparison of incremental concentrations of micron-sized superparamagnetic iron oxide for labelling articular cartilage derived chondroprogenitors. Acta Histochem. 2019 Oct;121 (7)791-797.
- Richard AJ, Rose JS, Korah S, Keziah M, Arambhan S, Arthi A, Jaisakthi SM, Vijayarajan V. Quantification of corneal transparency in post-mortem human corneas using laser scatter image analysis. Clin Exp Optom. 2019 Sep;102(5):485-488.
- Rana D, Kumar S, Webster TJ, Ramalingam M. Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration. Curr Osteoporos Rep. 2019 Aug;17(4):226-234.
- Vinod E, Kachroo U, Ozbey O, Sathishkumar S, Boopalan PRJVC. Comparison of human articular chondrocyte and chondroprogenitor cocultures and monocultures: To assess chondrogenic potential and markers of hypertrophy. Tissue Cell. 2019 Apr;57:42-48.
- Elizabeth Vinod, Deepak Vinod Francis, Soosai Manickam Amirtham, Solomon Sathishkumar, P.R.J.V.C Boopalan. Allogeneic platelet rich plasma serves as a scaffold for articular cartilage derived chondroprogenitors. Tissue Cell. 2019 Feb;56, 107-113.
- Rangasami VK, Lohchania B, Voshavar C, Rachamalla HR, Banerjee R, Dhayani A, Thangavel S, Vemula PK, Marepally S. Exploring membrane permeability of Tomatidine to enhance lipid mediated nucleic acid transfections. Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):327-334.
- Elizabeth Vinod, Jithu Varghese James, Arumugam Sabareeswaran, Soosai Manickam Amirtham a, George Thomas d, Solomon Sathishkumar, Ozlem Ozbey, P.R.J.V.C. Boopalan. Intraarticular injection of allogenic chondroprogenitors for treatment of osteoarthritis in rabbit knee model. J Clin Orthop Trauma. 2019 Jan-Feb;10(1) 16-23.
- Perumal G, Ramasamy B, Nandkumar AM, Doble M. Influence of magnesium particles and Pluronic F127 on compressive strength and cytocompatibility of nanocomposite injectable and moldable beads for bone regeneration. J Mech Behav Biomed Mater. 2018 Dec;88:453-462.
- Perumal G, Ramasamy B, A MN, Doble M. Nanostructure coated AZ31 magnesium cylindrical mesh cage for potential long bone segmental defect repair applications. Colloids Surf B Biointerfaces. 2018 Dec 1;172:690-698.
- Rajasekaran S, Thatte J, Periasamy J, Javali A, Jayaram M, Sen D, Krishnagopal A, Jayandharan GR, Sambasivan R. Infectivity of adeno-associated virus serotypes in mouse testis. BMC Biotechnol. 2018 Nov 1;18(1):70.
- Muripiti V, Mujahid TY, Boddeda VHV, Tiwari S, Marepally SK, Patri SV, Gopal V. Structure-activity relationship of serotonin derived tocopherol lipids. Int J Pharm. 2018 Oct 30;554:134-148.
- Sullivan S, Stacey GN, Akazawa C, Aoyama N, Baptista R, Bedford P, Bennaceur Griscelli A, Chandra A, Elwood N, Girard M, Kawamata S, Hanatani T, Latsis T, Lin S, Ludwig TE, Malygina T, Mack A, Mountford JC, Noggle S, Pereira LV, Price J, Sheldon M, Srivastava A, Stachelscheid H, Velayudhan SR, Ward NJ, Turner ML, Barry J, Song J. Quality control guidelines for clinical-grade human induced pluripotent stem cell lines. Regen Med. 2018 Oct;13(7):859-866.
- Doering CB, Denning G, Shields J, Fine EJ, Parker ET, Srivastava A, Lollar P, Spencer HT. Preclinical development of a hematopoietic stem and progenitor cell bioengineered factor VIII lentiviral vector gene therapy for hemophilia A. Hum Gene Ther. 2018 Oct;29(10):1183-1201.
- Kachroo U, Livingston A, Vinod E, Sathishkumar S, Boopalan PRJVC. Comparison of Electrophysiological Properties and Gene Expression between Human Chondrocytes and Chondroprogenitors Derived from Normal and Osteoarthritic Cartilage. Cartilage. 2018 Aug 23:1947603518796140. doi: 10.1177/1947603518796140. [Epub ahead of print]
- Rana D, Wang X, Webster TJ, Ramalingam M. Biomimetic Nanohydroxyapatite Synthesized With/Without Tris-Buffered Simulated Body Fluid: A Comparative Analysis. J Nanosci Nanotechnol. 2018 Jun 1;18(6):4423-4427.
- Pincha N, Hajam EY, Badarinath K, Batta SPR, Masudi T, Dey R, Andreasen P, Kawakami T, Samuel R, George R, Danda D, Jacob PM, Jamora C. PAI1 mediates fibroblast-mast cell interactions in skin fibrosis. J Clin Invest. 2018 May 1;128(5):1807-1819.
- Manian KV, Bharathan SP, Maddali M, Srivastava VM, Srivastava A, Velayudhan SR. Generation of an integration-free iPSC line (CSCRi005-A) from erythroid progenitor cells of a healthy Indian male individual. Stem Cell Res. 2018 Apr 3;29:148-151.
- Bhullar SK, Rana D, Ozsel BK, Orhan M, Jun MBG, Buttar HS, Ostrovidov S, Ramalingam M. Development of Silver-Based Bactericidal Composite Nanofibers by Airbrushing. J Nanosci Nanotechnol. 2018 Apr 1;18(4):2951-2955.
- Jayasree R, Madhumathi K, Rana D, Ramalingam M, Nankar RP, Doble M, Kumar TSS. Development of Egg Shell Derived Carbonated Apatite Nanocarrier System for Drug Delivery. J Nanosci Nanotechnol. 2018 Apr 1;18(4):2318-2324.
- Vinod E, Boopalan PRJVC, Arumugam S, Sathishkumar S. Creation of monosodium iodoacetate-induced model of osteoarthritis in rabbit knee joint. Indian J Med Res. 2018 Mar;147(3):312-314.
- Mahlangu J, Cerquiera M, Srivastava A. Emerging therapies for haemophilia – Global perspective. Haemophilia. 2018 May;24 Suppl 6:15-21.
- Muripiti V, Lohchania B, Marepally SK, Patri SV. Hepatocellular targeted α-tocopherol based pH sensitive galactosylated lipids: design, synthesis and transfection studies. Medchemcomm. 2018 Feb 1; 9(2): 264–274.
Text Books
- Haidar and R. Murugan. Bioceramics: Principles and Applications. Wiley-Scrivener Publication, USA. (Jul 2018)
- Bhullar SK, Rana D, Lekesiz H, Bedeloglu AC, Ko J, Cho Y, Aytac Z, Uyar T, Jun M, Ramalingam M.Design and fabrication of auxetic PCL nanofiber membranes for biomedical applications. Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:334-340.
- Priya Dharmalingam, Hari Krishna R. Rachamalla, Brijesh Lohchania, Bhanuprasad Bandlamudi, Saravanabhavan Thangavel, Mohankumar K. Murugesan, Rajkumar Banerjee, Arabinda Chaudhuri, Chandrashekhar Voshavar, and Srujan Marepally. Green Transfection: Cationic Lipid Nanocarrier System Derivatized from Vegetable Fat, Palmstearin Enhances Nucleic Acid Transfections. ACS Omega, 2017, 2 (11), pp 7892–7903.
- Abbas S, Kini A, Srivastava VM, M MT, Nair SC, Abraham A, Mathews V, George B, Kumar S, Venkatraman A, Srivastava A. Coexistence of aberrant hematopoietic and stromal elements in myelodysplastic syndromes. Blood Cells Mol Dis. 2017 Jul;66:37-46.
- Rana D, Ramalingam M. Enhanced proliferation of human bone marrow derived mesenchymal stem cells on tough hydrogel substrates. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1057-1065.
- Gabriel N, Samuel R, Jayandharan GR. Targeted delivery of AAV-transduced mesenchymal stromal cells to hepatic tissue for ex vivo gene therapy. J Tissue Eng Regen Med. 2017 May;11(5):1354-1364.
- Karathedath S, Rajamani BM, Musheer Aalam SM, Abraham A, Varatharajan S, Krishnamurthy P, Mathews V, Velayudhan SR, Balasubramanian P. The role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2. PLoS One. 2017 May 15;12(5):e0177227.
- Rana D, Zreiqat H, Benkirane-Jessel N, Ramakrishna S, Ramalingam M. Development of decellularized scaffolds for stem cell-driven tissue engineering. J Tissue Eng Regen Med. 2017 Apr;11(4):942-965.
- Sumitha Prameela Bharathana, Krittika Nandy, Dhavapriya Palani, Nancy Beryl Janet A, Kasthuri Natarajan, Biju George, Alok Srivastava, Shaji Ramachandran Velayudhan. Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation.Stem Cell Research Volume 20, April 2017, Pages 54–57.
- Priya Dharmalingam, Balakrishna Marrapu, Chandrashekhar Voshavar, Rasagna Nadella, Vignesh Kumar Rangasami, R.V. Shajia, Salar Abbas, R.B.N. Prasadb, Shiva Shanker Kakib, Srujan Marepallya. An antioxidant, α-lipoic acid conjugated oleoyl-sn-phosphatidylcholine as a helper lipid in cationic liposomal formulations. Colloids and Surfaces B: Biointerfaces Volume 152, 1 April 2017, Pages 133–142.
- S. Prakash Parthiban, Deepti Rana, Esmaiel Jabbari, Nadia Benkirane-Jessel, Murugan Ramalingam. Covalently immobilized VEGF-mimicking peptide with gelatin methacrylate enhances microvascularization of endothelial cells. Acta Biomaterialia 2017 Mar 15;51:330-340.
- Ostrovidov S, Ahadian S, Ramon-Azcon J, Hosseini V, Fujie T, Parthiban SP, Shiku H, Matsue T, Kaji H, Ramalingam M, Bae H, Khademhosseini A. Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function. J Tissue Eng Regen Med. 2017 Feb;11(2):582-595.
- Alok Srivastava, Ramachandran V. Shaji. Cure For Thalassemia Major: From Allogeneic Hematopoietic Stem Cell Transplantation To Gene Therapy. Haematologica 2017 Feb;102(2):214-223.
- Sumitha Prameela Bharathan, Kannan Vrindavan Manian, Syed Mohammed Musheer Aalam, Dhavapriya Palani, Prashant Ajit Deshpande, Mankuzhy Damodaran Pratheesh, Alok Srivastava, Shaji Ramachandran Velayudhan. Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Biology Open 2017 Jan 15;6(1):100-108.
Book Chapters
- Balasubramanian Sundaram, Anne George Cherian, Sanjay Kumar. 3D Decellularized Native Extracellular Matrix Scaffold for In Vitro Culture Expansion of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells (hWJ MSCs). Methods in Molecular Biology pp 1-19 2017 Sep 26.
- Balasubramanian Sundaram, Franklin Jebaraj Herbert, Sanjay Kumar. Human Mesenchymal Stem Cell (hMSC) -Derived Exosomes/Exosome Mimetics as a Potential Novel Therapeutic Tool for Regenerative Medicine. Regenerative Medicine: Laboratory to Clinic pp 81-97, 13 June 2017.
- Sabapathy V, Sundaram B, Kumar S. Therapeutic Application of Human Wharton Jelly Mesenchymal Stem Cells in Skin Injury of SCID. Methods Mol Biol. 2017;1553:115-132.
- Sabapathy V, Herbert FJ, Kumar S. Therapeutic Application of Placental Mesenchymal Stem Cells Reprogrammed Neurospheres in Spinal Cord Injury of SCID. Methods Mol Biol. 2017;1553:91-113.
- Madhuri, Vrisha & Rajagopal, Karthikeyan & Ramesh, Sowmya. Physeal Regeneration: From Bench to Bedside. Regenerative Medicine: Laboratory to Clinic (2017). 10.1007/978-981-10-3701-6_27.
Text Books
- R. Murugan and S. Ramakrishna. Nanofiber Composite Materials for Biomedical Applications. Elsevier Publication, UK. (25th January 2017).
- Z. Haidar and R. Murugan. Bioceramics: Principles and Applications. Wiley-Scrivener Publication, USA. (2017 - In process)
- Cell Reprogram. 2016 Nov;18(6):367-368. Identification of Stable OCT4+NANOG- State in Somatic Cell Reprogramming. Aalam SM, Manian KV, Bharathan SP, Mayuranathan T, Velayudhan SR.
- J Cell Mol Med. 2016 Aug;20(8):1571-88. hiPSCs derived iMSCs: NextGen MSCs as an advanced therapeutically active cell resource for regenerative medicine. Sabapathy V, Kumar S.
- Biomater. Tissue Eng.Volume 6, Number 7, July 2016, pp. 549-562. Decellularized Amniotic Membrane Scaffold Compared to Synthetic PLGA and Hybrid Scaffolds Exhibit Superlative Biomechanical Properties for Tissue Engineering Applications Vikram Sabapathy, Manju Hurakadli, Deepti Rana, Murugan Ramalingam, and Sanjay Kumar J.
- Bone Joint Res. 2016 Jul;5(7):301-6. WISP3 mutational analysis in Indian patients diagnosed with progressive pseudorheumatoid dysplasia and report of a novel mutation at p.Y198. Madhuri V, Santhanam M, Rajagopal K, Sugumar LK, Balaji V.
- Biotechnol Prog. 2016 May;32(3):554-67. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. Rana D, Ramasamy K, Leena M, Jiménez C, Campos J, Ibarra P, Haidar ZS, Ramalingam M.
- RSC Adv., 2016, 6, 20475-20484. Cell-laden alginate/polyacrylamide beads as carriers for stem cell delivery: preparation and characterization. Deepti Rana, Aleya Tabasuma and Murugan Ramalingam.
- Cell Stem Cell. 2016 Feb 4;18(2):214-28. The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC8, Li L.
- Curr Stem Cell Res Ther. 2016;11(2):99-113. Quest for alternate personalized clinical source of MSCs: Advancing towards hiPSCs derived iMSCs. Sabapathy V, Kumar S.
- Curr Stem Cell Res Ther. 2016;11(2):97-98. Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells: Ushering of a New Era in Personalized Cell Therapies. Pal R, Mariappan I, Velayudhan SR.
- Semin Hematol. 2016 Jan;53(1):3-9. Factor VIII/factor IX prophylaxis for severe hemophilia. Carcao M, Srivastava A.
- Eur J Immunol. 2016 Jan;46(1):154-66. Synergistic inhibition of PARP-1 and NF-?B signaling downregulates immune response against recombinant AAV2 vectors during hepatic gene therapy. Hareendran S, Ramakrishna B, Jayandharan GR.
- Cytotherapy. 2016 Jan;18(1):120-3. Part 2: Making the "unproven" "proven". Weiss DJ, Rasko JE, Cuende N, Ruiz MA, Ho HN, Nordon R, Wilton S, Dominici M, Srivastava A.
- Cytotherapy. 2016 Jan;18(1):117-9. Part 1: Defining unproven cellular therapies. Srivastava A, Mason C, Wagena E, Cuende N, Weiss DJ, Horwitz EM, Dominici M.
- Cell Reprogram. 2015 Dec;17(6):427-40. Understanding the Molecular Basis of Heterogeneity in Induced Pluripotent Stem Cells. Manian KV, Aalam SM, Bharathan SP, Srivastava A, Velayudhan SR.
- Clin Case Rep. 2015 Dec 1;4(1):87-9. Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India. George R, Santhanam S, Samuel R, Chapla A, Hilmarsen HT, Braathen GJ, Reinholt FP, Jahnsen F, Khnykin D.
- Cytotherapy 2015 Dec;17(12):1663-6. Positioning a Scientific Community on Unproven Cellular Therapies: The 2015 International Society for Cellular Therapy Perspective. Dominici M, Nichols K, Srivastava A, Weiss DJ, Eldridge P, Cuende N, Deans RJ, Rasko JE, Levine AD, Turner L, Griffin DL, O’Donnell L, Forte M, Mason C, Wagena E, Janssen W, Nordon R, Wall D, Ho HN, Ruiz MA, Wilton S, Horwitz EM, Gunter KC; 2013–2015 ISCT Presidential Task Force on Unproven Cellular Therapy.
- Inflammatory Bowel Diseases, Volume 21, Issue 11, pg 2549–2561, November 2015. Aberrant Niche Signaling in the Etiopathogenesis of Ulcerative Colitis. Kini, Archana T.; Thangaraj, Kavitha R.; Simon, Ebby; Shivappagowdar, Abhishek ; Thiagarajan, Divya; Abbas, Salar ; Ramachandran, Anup; Venkatraman, Aparna.
- Nature Communications, Volume 6, Article 8574, 15 October 2015. The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. Nakasaki M, Hwang Y, Xie Y, Kataria S, Gund R, Hajam EY, Samuel R, George R, Danda D, M J P, Nakamura T, Shen Z, Briggs S, Varghese S, Jamora C.
- Science Translational Medicine 14 Oct 2015: Vol 7, Issue 309, pp 309rv6. Vascular diseases await translation of blood vessels engineered from stem cells. Rekha Samuel, Dan G. Duda, Dai Fukumura and Rakesh K. Jain.
- Annals of Human Genetics, Volume 79, Issue 4, pages 245–252, July 2015. Classical and Atypical Fibrodysplasia Ossificans Progressiva in India. Madhuri V, Santhanam M, Sugumar LK, Rajagopal K, Chilbule SK.
- Journal of Tissue Engineering and Regenerative Medicine (29 JUN 2015). Development of decellularized scaffolds for stem cell-driven tissue engineering. Deepti Rana, Hala Zreiqat, Nadia Benkirane-Jessel, Seeram Ramakrishna and Murugan Ramalingam.
- Journal of Tissue Engineering and Regenerative Medicine, in press (5 June 2015). Targeted delivery of AAV-transduced mesenchymal stromal cells to hepatic tissue for ex vivo gene therapy. Nishanth Gabriel, Rekha Samuel and Giridhara R. Jayandharan.
- Nanoscale. 2015 Apr 21;7(15):6436-43. Facile and green production of aqueous graphene dispersions for biomedical applications. S. Ahadian, M. Estili, J. Ramón-Azcón, X. Liang, H. Shiku, R. Murugan, H. Bae, K. Nakajima, T. Matsue, Y. Sakka, and A. Khademhosseini.
- Stem Cells Int. 2015;2015:606415. Noninvasive Optical Imaging and In Vivo Cell Tracking of Indocyanine Green Labeled Human Stem Cells Transplanted at Superficial or In-Depth Tissue of SCID Mice. Vikram Sabapathy, Joythsna Mentam, Paul Mazhuvanchary Jacob, and Sanjay Kumar.
- Stem Cells Int. 2015;2015:132172. Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions. Vikram Sabapathy, George Tharion and Sanjay Kumar.
- SAGE open medical case reports. January-December 2015; vol. 3, Jan 19, 2015. Spontaneous development of neoplasms in severe combined immunodeficient mice. Samuel R.
- Journal of Virology, 2015 Jan 15;89(2):952-61. Enhanced transgene expression from single-stranded D-sequence-substituted recombinant AAV vectors in human cell lines in vitro and in murine hepatocytes in-vivo. Chen Ling, Yuan Wang, Yuan Lu, Lina Wang, Giridhara R. Jayandharan, George V. Aslanidi, Baozheng Li, Binbin Cheng, Wenqin Ma, Thomas Lentz, Changquan Ling, Xiao Xiao, R. Jude Samulski, Nicholas Muzyczka and Arun Srivastava, CL and YW contributed equally.
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S.No |
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Journal Title/Volume/ Issue/Pg/Year |
PMID |
File / Link |
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1 |
R. Obregon, J. Ramón-Azcón, S. Ahadian, H. Shiku, H. Bae, R. Murugan, and T. Matsue. |
The use of microtechnology and nanotechnology in fabricating vascularized tissues. |
Journal of Nanoscience and Nanotechnolog, Volume:14/Issue:01, 487-500, January 2014. |
24730277 |
|
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2 |
S. Ahadian, J. Ramón-Azcón, H. Chang, X. Liang, H. Kaji, H. Shiku, K. Nakajima, R. Murugan, H. Wu, T. Matsue and A. Khademhosseini. |
Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films. |
RSC Advances, Volume:04, 9534, January 2014. |
Poulomi Adhikari |
|
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3 |
Ramesh B. Batchu, Oksana V. Gruzdyna, Amberly M. Moreno-Bost, Susann Szmania, Jayandharan GR, Arun Srivastava, Bala K. Kolli, Donald W. Weaver, Frits van Rhee, Scott A. Gruber. |
Efficient lysis of epithelial ovarian cancer cells by MAGE-A3-induced cytotoxic T lymphocytes using rAAV-6 capsid mutant vector |
Vaccine, Volume:32/Issue:08, 938-943, February 2014. |
24406390 |
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4 |
S. Ahadian, J. Ramón-Azcón, M. Estili, X. Liang, H. Shiku, R. Murugan, K. Nakajima, Y. Sakka, H. Bae, T. Matsue and A. Khademhosseini. |
Hybrid hydrogels containing vertically aligned carbon nanotubes with anisotropic electrical conductivity for muscle myofiber fabrication. |
Scientific Reports, Volume 4, Article number: 4271, March 2014. |
24642903 |
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5 |
Kaarunya Sampathkumar, Shylaja Arulkumar and Murugan Ramalingam. |
Advances in stimuli responsive nanobiomaterials for cancer therapy. |
Journal of Biomedical Nanotechnology, Volume:10/Issue:03, 367-382, March 2014. |
24730233 |
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6 |
Vikram Sabapathy, Balasubramanian Sundaram, Sreelakshmi VM, Pratheesh Mankuzhy, Kumar S. |
Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth. |
PLoS One, Volume:09/Issue:04, e93726, April 2014. |
24736473 |
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7 |
Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG. |
Differential effects of sorafenib on liver versus tumor fibrosis mediated by SDF1a/CXCR4 axis and Gr-1+ myeloid cell infiltration in mice. |
Hepatology, Volume:59/Issue:04, 1435-1447, April 2014. |
24242874 |
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8 |
Varadarajan, R. Balu, Deepti Rana, Murugan Ramalingam, and T. S. Sampath Kumar. |
Accelerated Sonochemical Synthesis of Calcium Deficient Hydroxyapatite Nanoparticles: Structural and Morphological Evolution. |
Journal of Biomaterials and Tissue Engineering, Volume:04/Issue:04, 295-299, April 2014. |
- |
|
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9 |
Balakrishnan B, Jayandharan GR. |
Basic biology of Adeno-associated virus (AAV) vectors used in gene therapy. |
Current Gene Therapy, Volume:14/Issue:02, 86-100, April 2014. |
24588706 |
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10 |
Sen D, Balakrishnan B, Jayandharan GR. |
Cellular unfolded protein response against viruses used in gene therapy. |
Frontiers in Microbiology, Volume:26, 250, May 2014. |
24904562 |
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11 |
Mayuranathan T, Rayabaram J, Das R, Arora N, Edison ES, Chandy M, Srivastava A,Velayudhan SR. |
Identification of rare and novel deletions that cause (δβ)0-thalassaemia and hereditary persistence of foetal haemoglobin in Indian population. |
European Journal of Haematology, Volume:92/Issue:06, 514-520, June 2014. |
24471888 |
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12 |
Deepti Rana, T.S. Sampath Kumar and Murugan Ramalingam. |
Cell-laden hydrogels for tissue engineering. |
Journal of Biomaterials and Tissue Engineering Volume:04/issue:07, 507–535, July 2014. |
- |
|
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13 |
S. Ostrovidov, X. Shi, L. Zhang, X. Liang, S. B. Kim, T. Fujie, R. Murugan, M. Chen, K. Nakajima, F. Al-Hazmi, H. Bae, A. Memic and A. Khademhosseini. |
Myotube formation on gelatin nanofibers-multiwalled carbon nanotubes hybrid scaffolds. |
Biomaterials, Volume:35(/Issue:04, 6268-6277, August 2014. |
24831971 |
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14 |
Samuel R, Ramanathan K, Mathews JE, Seshadri MS. |
Back to the future: examining type 2 diabetic vasculature using the gestational diabetic placenta. |
Diabetes & Vascular Disease Research, Volume:11/Issue:05, 363-365, September 2014. |
25116005 |
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15 |
Amirtharaj GJ, Thangaraj KR, Kini A, Raghupathy V, Goel A, Eapen CE, Venkatraman A, Pulimood AB, Balasubramanian KA and Ramachandran A. |
Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow. |
Toxicology Reports, Volume:01, 707-717, September 2014. |
28962284 |
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16 |
S. Ostrovidov, V. Hosseini, S. Ahadian, T. Fujie, S. P. Parthiban, R. Murugan, H. Bae, H. Kaji and A. Khademhosseini. |
Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications |
Tissue Engineering Part B: Reviews, Volume:20/Issue:05, 403-436, October 2014. |
24320971 |
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17 |
J. Ramón-Azcón, S. Ahadian, R. Obregon, H. Shiku, R. Murugan and T. Matsue. |
Applications of carbon nanotubes in stem cell research. |
Journal of Biomedical Nanotechnology, Voulme:10/Issue:10, 2539-2561, October 2014. |
25992408 |
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18 |
Selot R, Hareendran S, Jayandharan GR. |
Developing immunologically inert adeno-associated virus (AAV) vectors for gene therapy: possibilities and limitations. |
Current Pharmaceutical Biotechnology, Volume:14/Issue:12, 1072-1082, November 2014. |
24678652 |
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19 |
Meng Zhao, John M Perry, Heather Marshall , Aparna Venkatraman, Pengxu Qian, Xi C He, Jasimuddin Ahamed, & Linheng Li.< |
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. |
Nature Medicine, Volume:20/Issue:11, 1321–1326, November 2014 |
25326798 |
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20 |
Andea AA, Patel R, Ponnazhagan S, Isayeva T, Kumar S, Siegal GP. |
Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of Merkel cell carcinoma and correlation with prognosis. |
Romanian Journal of Morphology and Embryology, Volume:55/Issue: 03 Suppl., 1057-1062, November 2014. |
25607385 |
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S.No |
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Article Title |
Journal Title/Volume/ Issue/Pg/Year |
PMID |
File / Link |
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1 |
Balakrishnan B, Sen D, David S, Hareendran S, Srivastava A, Jayandharan GR. |
Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. |
PLoS One, Volume:08/Issue:01, e53845, January 2013. |
23320106 |
||||||
|
2 |
Sen D, Chapla A, Walter N, Daniel V, Srivastava A, Jayandharan GR. |
Nuclear Factor (NF)-?B and its associated pathways are major regulators of blood induced joint damage in a murine model of hemophilia. |
Journal of Thrombosis and Haemostasis, Volume: 11/Issue:02, 293-306, February 2013. |
23231432 |
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|
3 |
George VC, Ragupathi D, Kumar N, Suresh PK, Kumar S, Ashok Kumar R. |
Comparative Studies to Evaluate Relative in vitro Potency of Luteolin in Inducing Cell Cycle Arrest and Apoptosis in HaCaT and A375 Cells. |
Asian Pacific Journal of Cancer Prevention, Volume:14/Issue:02, 631-637, February 2013. |
23621210 |
||||||
|
4 |
Song L, Li X, Jayandharan GR, Wang Y, Aslanidi GV, Ling C, Zhong L, Gao G, Yoder MC, Ling C, Tan M, Srivastava A. |
High-efficiency transduction of primary human hematopoietic stem cells and erythroid lineage-restricted expression by optimized AAV6 serotype vectors in vitro and in a murine xenograft model in vivo. |
PLoS One, Volume:08/Issue:03, e58757, March 2013. |
23516552 |
||||||
|
5 |
Gabriel N, Hareendran S, Sen D, Gadkari RA, Govindarajan S, Hussain M, Duraiswamy R, Samuel R, Srinivasan N, Srivastava A, Jayandharan GR. |
Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo. |
Human Gene Therapy Methods, Volume:24/Issue:02, 80-93, April 2013. |
23379478 |
||||||
|
6 |
Sen D, Gadkari RA, Sudha G, Gabriel N, Sathish Kumar Y, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC,Srinivasan N, Srivastava A, Jayandharan GR. |
Targeted modifications in adeno-associated virus (AAV) serotype -8 capsid improves its hepatic gene transfer efficiency in vivo. |
Human Gene Therapy Methods, Volume:24/Issue:02, 104-116, April 2013. |
23442071 |
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|
7 |
S. Ahadian, S. Ostrovidov, V. Hosseini, H. Kaji,R. Murugan, H. Bae and A. Khademhosseini. |
Electrical stimulation as a biomimicry tool for regulating muscle cell behavior. |
Organogenesis, Volume:09/Issue:02, 87-92, April-June 2013. |
23823664 |
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|
8 |
Sen D, Balakrishnan B, Gabriel N, Agrawal P, Roshini V, Samuel R, Srivastava A, Jayandharan GR. |
Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy. |
Scientific Reports, Volume 3, Article number: 1832, May 2013. |
23665951 |
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|
9 |
Samuel R, Laurence Daheron, Shan Liao, Trupti Vardam, Walid S. Kamoun, Ana Batista, Christa Buecker, Richard Schäfer, Xiaoxing Han, Patrick Au, David T. Scadden, Dan G. Duda, Dai Fukumura, and Rakesh K. Jain. |
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. |
Proceedings of the National Academy of Sciences of the United States of America, Volume:110/Issue:31, 12774-12779, July 2013. |
23861493 |
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31) 12774-9 |
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|
10 |
Seidi, K. Sampathkumar, A. Srivastava, S. Ramakrishna and R. Murugan. |
Gradient nanofiber scaffolds for tissue engineering. |
Journal of Nanoscience and Nanotechnology, Volume:13/Issue:07, 4647-4655, July 2013. |
23901487 |
||||||
|
11 |
Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK. |
Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression. |
Journal of the National Cancer Institute, Volume:105/Issue:16, 1188-1201, August 2013. |
23899555 |
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|
12 |
Viswanathan S, Rao M, Keating A, Srivastava A. |
Overcoming challenges to initiating cell therapy clinical trials in rapidly developing countries: India as a model. |
Stem Cells Translational Medicine, Volume:02/Issue:08, 607-613, August 2013. |
23836804 |
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|
13 |
Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. |
Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. |
Nature, Volume:500/Issue:7462, 345-349, August 2013. |
23863936 |
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|
14 |
Song L, Kauss MA, Kopin E, Chandra M, Ul-Hasan T, Miller E, Jayandharan GR, Rivers AE, Aslanidi GV, Ling C, Li B, Ma W, Li X, Andino LA, Zhong L, Tarantal AF, Yoder MC, Wong KK, Jr, Tan M, Chatterjee S, Srivastava A. |
Optimizing the transduction efficiency of human hematopoietic stem cells using capsid-modified AAV6 vectors in vitro and in a xenograft mouse model in vivo. |
Cytotherapy, Volume:15/Issue:08, 986-998, August 2013. |
23830234 |
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|
15 |
J. Ramón-Azcón, S. Ahadian, M. Estili, X. Liang, S. Ostrovidov, H. Kaji,H. Shiku, R. Murugan, K. Nakajima, Y. Sakka, A. Khademhosseini, T. Matsue. |
Dielectrophoretically aligned carbon nanotubes to control electrical and mechanical properties of hydrogels to fabricate contractile muscle myofibers. |
Advanced Materials, Volume: 25/Issue: 29, 4028-4034, August 2013. |
23798469 |
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16 |
Sangeetha H, Balakrishnan B, Sen D, Kumar S, Srivastava A, Jayandharan GR. |
Adeno-associated virus (AAV) vectors in gene therapy: Immune challenges and strategies to circumvent them. |
Reviews in Medical Virology, Volume:23/Issue:06, 399-413, November 2013. |
24023004 |
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S.No |
Title |
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ISBN |
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File / Link |
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|
1 |
Micro and Nanotechnologies in Engineering Stem Cells and Tissues. Volume 39 of IEEE Press Series on Biomedical Engineering. |
Murugan Ramalingam, Esmaiel Jabbari, Seeram Ramakrishna, Ali Khademhosseini |
John Wiley & Sons, June 2013 |
Print ISBN: 9781118140420 Online ISBN: 9781118574775 |
Science / Biotechnology, 328 pages |
|||||
|
2 |
Biomimetics: Advancing Nanobiomaterials and Tissue Engineering |
Murugan Ramalingam, Xiumei Wang, Guoping Chen, Peter MaFu-Zhai Cui |
John Wiley & Sons, August 2013 |
Print ISBN: 9781118469620 Online ISBN: 9781118810408 |
Science / Biotechnology, 384 Pages |
|||||
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S.No |
Title |
Author |
Book Title |
Book Editors |
Pages / Year |
File / Link |
|
1 |
Chapter 12 - The Emerging Applications of Graphene Oxide and Graphene in Tissue Engineering. |
S. Ahadian, R. Murugan and A. Khademhosseini. |
Biomimetics: Advancing Nanobiomaterials and Tissue Engineering |
Murugan Ramalingam Xiumei Wang Guoping Chen Peter Ma Fu‐Zhai Cui |
279-299 / 2013 |
|
|
2 |
Chapter 14 - Biomimetic Materials for Engineering Stem Cells and Tissues |
Kaarunya Sampathkumar, Azadeh Seidi, Alok Srivastava, T.S. Sampath Kumar, Seeram Ramakrishna, Murugan Ramalingam. |
Biomimetics: Advancing Nanobiomaterials and Tissue Engineering |
Murugan Ramalingam Xiumei Wang Guoping Chen Peter Ma Fu‐Zhai Cui |
329-344 / 2013 |
|
|
3 |
Chapter 2 - Nanofiber technology for controlling stem cell functions and tissue engineering. |
M. Shayanthi, J. Venugopal, R. Rajeswari, R. Murugan, M. Raghunath and S. Ramakrishna. |
Micro and Nanotechnologies in Engineering Stem cells and Tissues. |
Murugan Ramalingam, Esmaiel Jabbari, Seeram Ramakrishna, Ali Khademhosseini |
27-52 / 2013 |
|
|
4 |
Chapter 3 - Micro- and nanoengineering approaches for advancing gradient biomaterials suitable for interface tissue engineering. |
S. Ostrovidov, A. Seidi, S. Ahadian, R. Murugan and A. Khademhosseini. |
Micro and Nanotechnologies in Engineering Stem cells and Tissues. |
Murugan Ramalingam, Esmaiel Jabbari, Seeram Ramakrishna, Ali Khademhosseini |
52-80 / 2013 |
|
|
5 |
Chapter 10 - Surface chemical determination of placement, growth and differentiation of cells for drug screening, toxin detection and lab-on-a-chip applications. |
Peter Molnar, MuruganMurugan, and James J. Hickman. |
Tissue Engineering and Regenerative Medicine: A Nano Approach |
R. Murugan, P. Vallittu. U. Ripamonti and Wan-Ju Li |
205-228 / 2013 |
|
|
6 |
Chapter 21 - Nanobiomaterial-Based Short Interfering RNA Delivery Systems |
Y.N. Cho,R. Murugan and Z.S. Haidar. |
Tissue Engineering and Regenerative Medicine: A Nano Approach |
R. Murugan, P. Vallittu. U. Ripamonti and Wan-Ju Li |
473-498 / 2013 |
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S.No |
Author |
Article Title |
Journal Title/Volume/ Issue/Pg/Year |
PMID |
File / Link |
|||||
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1 |
V.Sabapathy, S. Ravi, V. Srivastava, A.Srivastava, and S.Kumar |
Long-term cultured human term placenta-derived mesenchymal stem cells of maternal origin displays plasticity. |
Stem Cells International, Volume: 2012, Article ID:174328, 11 pages. |
22550499 |
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|
2 |
Zhong L, Jayandharan GR, Aslanidi G, Zolutukin S, Herzog RW, Srivastava A. |
Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia. |
Journal of Genetic Syndromes & Gene therapy, Volume: S/Issue:01, 1-8, January 2012. |
23264889 |
||||||
|
3 |
Jayandharan GR, Srivastava A, Srivastava A. |
Role of molecular genetics in hemophilia: from diagnosis to therapy. |
Seminars in Thrombosis and Hemostasis, Volume:38/Issue:01, 64-78, February 2012. |
22314605 |
||||||
|
4 |
Scadden D, Srivastava A. |
Advancing stem cell biology toward stem cell therapeutics. |
Cell Stem Cell, Volume: 10/Issue:02, 149-150, February 2012. |
22305564 |
||||||
|
5 |
Kumar S, Ponnazhagan S. |
Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect. |
Bone, Volume:50/Issue:04, 1012-1018, April 2012. |
22342795 |
||||||
|
6 |
Aslanidi GV, Rivers AE, Ortiz L, Govindasamy L, Ling C, Jayandharan GR, Zolotukhin S, Agbandje-McKenna M, Srivastava A. |
High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors. |
Vaccine, Volume: 30/Issue:26, 3908-3917, June 2012. |
22497875 |
||||||
|
7 |
Sukumaran A, Venkatraman A, Jacob M. |
Inflammation-induced effects on iron-related proteins in splenic macrophages and the liver in mice. |
Blood Cells, Molecules & Diseases, Volume:49/Issue:01, 11-19, June 2012. |
22504041 |
||||||
|
8 |
Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong X, Suda Tand Li L. |
Non-canonical Wnt signaling maintains hematopoietic stem cells in the niche. |
Cell, Volume:150/Issue:02, 351-65, July 2012 |
22817897 |
||||||
|
9 |
A. C. Goodeve, D. J. Perry, T. Cumming, M. Hill, I. Jennings, S. Kitchen, I. Walker, E. Gray, G. R. Jayandharan, E. Tuddenham. |
Genetics of haemostasis. |
Haemophilia, Volume:18/Issue: Suppl. 4, 73-80, July 2012. |
22726087 |
||||||
|
10 |
Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree M, Deng C-X, Lapidot Y, He XC, and Li L. |
FGF signaling facilitates post-injury recovery of mouse hematopoietic system. |
Blood, Volume: 120/Issue:09, 1831-1842, August 2012. |
22802336 |
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S.No |
Title |
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|
1 |
Tissue Engineering and Regenerative Medicine: A Nano Approach. |
Regenerative Medicine: A Nano Approach. R. Murugan, P. Vallittu, U. Ripamonti and Wan-Ju Li. |
CRC Press, 2012 |
9781439881866 |
Technology & Engineering / Materials Science 592 pages |
|||||
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S.No |
Author |
Article Title |
Journal Title/Volume/ Issue/Pg/Year |
PMID |
File / Link |
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1 |
Petrs-Silva H, Dinculescu A, Li Q, Deng WT, Pang JJ, Min SH, Chiodo V, Neeley AW, Govindasamy L, Bennett A, Agbandje-McKenna M, Zhong L, Li B, Jayandharan GR, Srivastava A, Lewin AS, Hauswirth WW. |
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina. |
Molecular Therapy, Volume:19/Issue:02, 293-301, February 2011. |
21045809 |
|
|
2 |
Jayandharan GR, Aslanidi G, Martino AT, Jahn SC, Perrin GQ, Herzog RW, Srivastava A. |
Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy. |
Proceedings of the National Academy of Sciences of the United States of America, Volume: 108/Issue:09, 3743-3748, March 2011. |
21321191 |
|
|
3 |
Ma W, Li B, Ling C, Jayandharan GR, Srivastava A, Byrne BJ. |
A simple method to increase the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo. |
Human Gene Therapy, Volume:22/Issue:05, 633-640, May 2011. |
21219084 |
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4 |
Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L. |
PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. |
Clinical Cancer Research, Volume:17/Issue:11, 3638-3648, June 2011. |
21459800 |
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|
5 |
Rogers GL, Martino AT, Aslanidi GV, Jayandharan GR, Srivastava A, Herzog RW. |
Innate Immune Responses to AAV Vectors. |
Frontiers in Microbiology, Volume:02, 194, September 2011. |
21954398 |
|
|
6 |
Jayandharan GR, Srivastava A. |
Hemophilia: genetics, diagnosis and management. |
Genetic Syndromes & Gene Therapy, Volume: S1/Issue:005, 1-12, November 2011. |
- |
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S.No |
Author |
Article Title |
Journal Title/Volume/ Issue/Pg/Year |
PMID |
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1 |
Jayandharan GR, Zhong L, Sack BK, Rivers AE, Li M, Li B, Herzog RW, Srivastava A. |
Optimized adeno-associated virus (AAV)-protein phosphatase-5 helper viruses for efficient liver transduction by single-stranded AAV vectors: therapeutic expression of factor IX at reduced vector doses. |
Human Gene Therapy, Volume: 21/Issue: 03, 271-283, March 2010. |
19788390 |
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2 |
Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL. |
Patientsbeware: commercializedstem celltreatments on the web. |
Cell Stem Cell, Volume: 07/Issue: 01, 43-49, July 2010. |
20621049 |
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3 |
Hareendran S, Sathishkumar S, Abbas S, Mackay AM, Rajan P. |
A novel composition for the culture of human adipose stem cells which includes complement C3. |
Cytotechnology, Volume: 62/Issue: 05, 389-402, October 2010. |
20835846 |
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4 |
Qiao C, Zhang W, Yuan Z, Shin JH, Li J, Jayandharan GR, Zhong L, Srivastava A, Xiao X, Duan D. |
Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle. |
Human Gene Therapy, Volume: 21/Issue: 10, 1343-1348, October 2010. |
20497037 |
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5 |
Li M, Jayandharan GR, Li B, Ling C, Ma W, Srivastava A, Zhong L. |
High-efficiency transduction of fibroblasts and mesenchymal stem cells by tyrosine-mutant AAV2 vectors for their potential use in cellular therapy. |
Human Gene Therapy, Volume: 21/Issue: 11, 1527-1543, November 2010. |
20507237 |
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6 |
Ling C, Lu Y, Kalsi JK, Jayandharan GR, Li B, Ma W, Cheng B, Gee SW, McGoogan KE, Govindasamy L, Zhong L, Agbandje-McKenna M, Srivastava A. |
Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3. |
Human Gene Therapy, Volume: 21/Issue: 12, 1741-1747, December 2010. |
20545554 |
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7 |
Markusic DM, Herzog RW, Aslanidi GV, Hoffman BE, Li B, Li M, Jayandharan GR, Ling C, Zolotukhin I, Ma W, Zolotukhin S, Srivastava A, Zhong L |
High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines. |
Molecular Therapy, Volume: 18/Issue: 12, 2048-2056, December 2010. |
20736929 |
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S.No |
Author |
Article Title |
Journal Title/Volume/ Issue/Pg/Year |
PMID |
File / Link |
|
1 |
Hareendran S, Abbas, S, Rajan P |
Signaling and epigenetic mechanisms regulating stem cells. |
Gene Therapy and Molecular Biology, Volume: 13, 130-143, June 2009. |
- |
Gene-Therapy-and-Molecular-Biology-Volume-13-130-143-June-2009 |
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2 |
Srivastava A. |
Indian Academy of Neurology: The Dasgupta Oration 2009, Neural regeneration with stem cells: Rebooting the brain. |
Annals of Indian Academy of Neurology, Volume: 12, Issue: 03, 138-139, July 2009. |
20174492 |
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3 |
Lin IJ, Zhou Z, Crusselle-Davis VJ, Moghimi B, Gandhi K, Anantharaman A, Pantic D, Huang S, Jayandharan G, Zhong L, Srivastava A, Bungert J. |
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells. |
Journal of Biological Chemistry, Volume: 284, Issue: 30, 20130-20135, July 2009. |
19491096 |
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4 |
Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. |
Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer |
Cancer Research, Volume: 69/Issue: 20, 7905-7910, October 2009. |
19826039 |
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S.No |
Author |
Article Title |
Journal Title/Volume/ Issue/Pg/Year |
PMID |
File / Link |
|
1 |
Jayandharan GR, Zhong L, Li B, Kachniarz B, Srivastava A. |
Strategies for improving the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo. |
Gene Therapy Volume: 15, Issue: 18,1287-1293, September 2008. |
18496572 |
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2 |
Zhong L, Li B, Jayandharan G, Mah CS, Govindasamy L, Agbandje-McKenna M, Herzog RW, Weigel-Van Aken KA, Hobbs JA, Zolotukhin S, Muzyczka N, Srivastava A. |
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression. |
Virology, Volume: 381, Issue: 02, 194-202, November 2008. |
18834608 |
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3 |
Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, Kim HO, Lee HP, Levy-Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke |
New ISSCR guidelines underscore major principles for responsible translational stem cell research. |
Cell Stem Cell, Volume: 3, Issue: 06, 607-609, December 2008. |
19041777 |