9th Annual Cell and Gene Therapy Symposium

Centre for Stem Cell Research (a unit of inStem, Bengaluru), Christian Medical College Campus, Vellore

Scientific Program

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1st  to 3rd  August, 2024

PROGRAMME SCHEDULE

DAY-1: Thursday, 1st  August, 2024

1:00 to 1:05 PM

 

1:05 to 1:20 PM

1:20 to 1:25 PM

1:25 to 1:30 PM

 ·         Prayer by Chaplain

 

·         Welcome remarks: Director, CMC / Director, InStem / Principal, CMC

·         Remarks by  Secretary, Department of Biotechnology, Ministry of Science and Technology, Govt. of India

·         Closing remarks: Head, CSCR

Session-1:  Orthobiologics in Cartilage Repair

Chair: Samuel Chittaranjan
India Time Title Speaker Name
1.30 to 2:00 PM Cell-Based Therapeutics for Arthritic Disease Frank Barry

University of Galway, Ireland
2:00 to 2:30 PM PRP for OA Knee: Bench to bedside Sandeep Patel

The Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
2:30 to 3:00 PM The Role of Extracellular Vesicles and Orthobiologics Secretome in Joint Preservation Elizabeth Vinod

Centre for Stem Cell Research (a unit of inStem, Bengaluru) and CMC, Vellore, India
3:00 to 3:30 PM                                              Poster presentation and Industry Exhibition

Session-2: MANUFACTURING AND REGULATORY ASPECTS IN CELL AND GENE THERAPY

Chair: Cartikeya Reddy
India Time Title Speaker Name
3:30 to 4:00 PM

Regulatory Paradigm of CAR-T therapies in India

and

Challenges and Promise of CAR-based therapies in India

 Akhil Kumar

Aurigene Oncology Limited, Bangalore, India

and

Priyadarshini Chatterjee

Aurigene Oncology Limited, Bangalore, India
4:00 to 4:30 PM From Innovation to Translation to Patients: The Future of Genetically Engineered T-Cells for Human Therapeutics Bruce L. Levine

The University of Pennsylvania, Philadelphia, US
4:30 to 5:00 PM Mesenchymal stromal cells for clinical applications: CMC Challenges and Paths Forward Sowmya Viswanathan

Schroeder Arthritis Institute, University Health Network and the University of Toronto, Ontario, Canada
5:00 to 5:15 PM Break

Session-3: TECHNOLOGY ADVANCES

Chair: Soniya Nityanand
India Time Title Speaker Name
5:15 to 5:45 PM Development of targeted viral platform for selective gene transfer to human HSCs in vivo Dmitry M. Shayakhmetov

Emory University School of Medicine Atlanta, USA
5:45 to 6:15 PM Genetic and Transcriptional Engineering of Primary Human Blood Cells Rasmus O. Bak

Aarhus University, Department of Biomedicine, Aarhus, Denmark
6:15 to 6:45 PM Innovative Non-Genotoxic Cell and Gene Therapies for Fanconi Anemia Agnieszka Czechowicz

Stanford University School of Medicine, Dept of Pediatrics Div. of Stem Cell Transplantation and Regenerative Medicine, Stanford, US

KEYNOTE ADDRESS
Chair: Alok Srivastava
India Time Title Speaker Name
6:45 to 7:45 PM The Concept of Innovation and Orchestration: Translating Engineered Cellular Therapies from Bench to Bedside Khalid Shah

Center for Stem Cell and Translational Immunotherapy, Brigham and Women’s Hospital and Harvard Stem Cell Institute, Cambridge, USA
End of Day-1

DAY-2: Friday, 2nd August, 2024

Session-4: INDUSTRY UPDATES
 Chair: Praveen Kumar Vemula
India Time Title Speaker Name
12:00  to 12:20 PM Non-Viral Chimeric Antigen Receptor (CAR) T Cells going Viral: Process Studies from Stanford Center for Cancer Cell Vimal Keerthi

Stanford University School of Medicine, California, US
12: 20 to 12:40 PM Writing the Future of Biologics with an Integrated Offering of Immunization, Libraries, and Machine Learning Jay Yang

Twist Bioscience, San Francisco, California, US
12:40 to 1:00 PM Transforming Viral Vector Production: Enhancing Efficiency and Scale-Up with OmniBRx’s Dynamic Bed Reactor Technology  Ravindra Patel

OmniBRx Biotechnologies Pvt Ltd. Ahmedabad, Gujarat, India
1:00 to 2:00 PM Lunch Break

Session-5: APPLICATION OF IPSC TECHHNOLOGY

                                                                                                                                                                           Chair: Maneesha S. Inamdar                                                                                                                                                                                                                                                                                                                                                       Co-Chair: Dhandapani Perundurai     
India Time Title Speaker Name
2:00 to 2:30 PM Challenges for the development of pluripotent stem cell-based therapies and the role of international standards. Glyn Stacey

International Stem Cell Banking Initiative, Barley, UK
2:30 to 3:00 PM Developing iPSC-derived RPE cell replacement therapy for the treatment of AMD Rajarshi Pal

Eyestem Research, Centre for Cellular and Molecular Platforms (C-CAMP), Bangalore, India
3:00 to 3:30 PM

Developing iPSC technologies to impact current challenges in the production of cell therapies

Julia Neubauer

Fraunhofer Institute for Biomedical Engineering IBMT, Germany 
3:30 to 3:45 PM Break

 Session-6: GENE THERAPY
Chair: Matthew Porteus
India Time Title Speaker Name
3:45 to 4.15 PM New insights into the use of gamma delta T cells to treat childhood cancers H. Trent Spencer

Emory University School of Medicine, Atlanta, USA
4:15 to 4:45 PM Development of genome-modified generation ZZ (GenZZ) single-stranded AAV vectors with improved transgene expression Arun Srivastava

University of Florida, Florida, USA
4:45 to 5:15 PM Preclinical development of gene therapy for Diamond-Blackfan anemia Senthil Bhoopalan

St. Jude Children’s Research Hospital, Memphis, USA
5:15 to 6:00 PM Poster presentation and Industry Exhibition

Session-7: Challenges And Opportunities in Gene Therapy
Chair: RV Shaji
India Time Title Speaker Name
6:00 to 6:30 PM Development of pathophysiologicallyrelevant models of β-hemoglobinopahtues for therapeutic studies

Sivaprakash Ramalingam

CSIR–Institute of Genomics and Integrative Biology (CSIR–IGIB), New Delhi, India
6:30 to 7:00 PM CAR T-cell induced T-cell malignancies Nirali Shah

Center for Cancer Research, National Cancer Institute, Maryland, US
7:00 to 7:30 PM Genome Editing of HSCs to Develop Stem Cell Based Therapies Matthew Porteus

Stanford School of Medicine, California, USA

KEYNOTE ADDRESS
Chair: Sanjay Singh
India Time Title Speaker Name
7:30 to 8:30 PM Gene therapy for Haemophilia in India – The beginning of a New Era Alok Srivastava

Centre for Stem Cell Research (A unit of inStem, Bengaluru) and Christian Medical College, Vellore, India

End of Day-2

 DAY-3: 3rd August 2024

Session-8: INDUSTRY UPDATES

Chair: Arvind Ramanathan
India Time Title Speaker Name
12:20 to 12:40 PM Autologous CAR-T Cell Therapy Manufacturing Solution Pankaj Salvi

Cytiva, Marlborough, US
12:40 to 01:00 PM Thermo Fisher Scientific: Cell & Gene Therapy capabilities overview Uchenna Waturuocha

Thermo Fisher Scientific, Mumbai, India
01:00 to 02:00 PM Lunch Break

Session-9: NON-VIRAL VECTOR BASED GENE THERAPY
Chair: N. Madhusudhana Rao
India Time Title Speaker Name
2:00 to 2:30 PM Enhancing Natural killer cells proliferation and cytotoxicity using Imidazole-based lipid nanoparticles encapsulating interleukin-2 mRNA Chantal Pichon

INSERM and University of Orléans, Orléans, France: Institut Universitaire de France, Paris
2:30 to 3:00 PM MSC Extracellular Vesicles: Navigating Regenerative Medicine’s Therapeutic Landscape Sujata Mohanty

All India Institute of Medical Sciences
New Delhi, India
3:00 to 3:30 PM

Long-lasting mRNA enabled protein replacement therapy with liver-specific lipid nanoparticle system: Haemophilia B as a model disease

Srujan Marepally

Centre for Stem Cell Research (a unit of inStem, Bengaluru), Vellore, India
3:30 to 3:45 PM Break
3:45 to 4:30 PM Poster presentation and Industry Exhibition

      Session-10: GENE EDITING

     Chair: Sanjeev Galande
India Time Title Speaker Name
4:30 to 5:00 PM Genome editing strategies for treating sickle cell disease Thiyagaraj Mayuranathan

Centre for Stem Cell Research (a unit of inStem, Bengaluru), Vellore, India
5:00 to 5:30 PM Epitope Editing for an Immunotherapy “Stealth” Hematopoiesis Pietro Genovese

Harvard Medical School, Boston, USA
5:30 to 6:00 PM Next-generation gene editing of human hematopoietic stem cells: from research to clinical translation Samuele Ferrari

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy

Session-11: IMMUNE CELL THERAPY

Chair: Amit Awasthi
India Time Title Speaker Name
6:00 to 6:30 PM CART Therapy in Pediatric Acute Lymphoblastic Leukemia Sunil Bhat

Mazumdar Shaw Medical Centre, Narayana Health City, Bangalore, India
6:30 to 7:00 PM Development of CAR-T cell products with non-viral vector system Yoshiyuki Takahashi

Nagoya University Graduate School of Medicine, Nagoya, Japan
7:00 to 7:30 PM Genetic manipulation of NK cells for enhanced immunotherapy Rizwan Romee

Harvard Medical School, Dana Farber Cancer Institute, Boston, USA

CONCLUDING REMARK

End of Day-3

Video Summary of the program – Click to view / Download

CGTS 2024 SCIENTIFIC PROGRAM – Click to view / Download

CGTS 2024 ABSTRACT BOOK – Click to view / download

CGTS 2024 E-POSTER – Click to view / download