Scientific Program

PROGRAMME SCHEDULE

Time shown in IST (Indian Standard Time)

DAY-1: Thursday, 31^stAugust, 2023

1:00 to 1:05 PM	Prayer by Chaplain
1:05 to 1:20 PM	Welcome remarks: Director, CMC / Director, InStem / Principal, CMC
1:20 to 1:25 PM	Remarks by Dr. Rajesh Gokhale, Secretary, Department of Biotechnology, Ministry of Science and Technology, Govt. of India
1:25 to 1:30 PM	Closing remarks: Head, CSCR

Session-1: CELL THERAPY IN CARTILAGE REPAIR Chair: George Thomas
Indian Time	Title	Speaker Name
1.30 to 1:55 PM	Autologous Chondrocyte Implantation (ACI): Evolution to current management and clinical outcomes	Mats Brittberg University of Gothenburg, Gothenburg, Sweden
1:55 to 2:20 PM	Cartilage regeneration in Osteoarthritis of knee: Reality or myth	Pawan Kumar Gupta Stempeutics Research Pvt. Ltd., Bangalore, India
2:20 to 2:40 PM	Potential of chondroprogenitors for cartilage repair and regeneration	Elizabeth Vinod Centre for Stem Cell Research (A unit of inStem, Bengaluru) and CMC, Vellore, India
2:40 to 3:00 PM	Articular chondroprogenitors: how close are we to a cell or tissue-based therapy for cartilage repair	Ilyas Khan Swansea University, Swansea, UK
3:00 to 3:15 PM	Break
3:15 to 3:45 PM	Poster presentation and Industry Exhibition
Session-2: SAFETY ASPECTS OF GENE THERAPY Chair: Vijay Chandru
Indian Time	Title	Speaker Name
3:45 to 4:15 PM	Precision in gene editing: towards next generation tools for therapy and diagnostics	Debojyoti Chakraborty CSIR Institute of Genomics and Integrative Biology, New Delhi, India
4:15 to 4:45 PM	Base editing and prime editing to treat genetic disease	Gregory Arthur Newby The Johns Hopkins University, Baltimore, US
4:45 to 5:15 PM	Understanding the safety or genome-wide activity of CRISPR genome editors for therapeutics	Shengdar Q. Tsai St. Jude Children’s Research Hospital, Memphis, TN
5:15 to 5:30 PM	Break
Session-3: MANUFACTURING AND REGULATORY ASPECTS IN CELL AND GENE THERAPY Chair: Sanjay Singh
Indian Time	Title	Speaker Name
5:30 to 6:00 PM	Current and future trends in gene therapy vector manufacturing	Ajay Singh Gennova Biopharma Ltd., Pune, India
6:00 to 6:30 PM	lentiviral manufacturing for use in phase I/II clinical trials	Daniela Bischof Indiana Clinical and Translational Sciences Institute, Indianapolis, IN
6:30 to 7:00 PM	Manufacturing of CAR T cells for Point-of-Care treatment of refractory hematological malignancies	Rupert Handgretinger Children’s University Hospital Tuebingen, Tuebingen, Germany
KEYNOTE ADDRESS Chair: Alok Srivastava
Indian Time	Title	Speaker Name
7:00 to 8:00 PM	Gene Therapy and Fetal Hemoglobin: Progress Toward a Cure for Sickle Cell Disease	Martin H. Steinberg Boston University School of Medicine, Boston, USA
End of Day-1
DAY-2: Friday, 1^stSEPTEMBER, 2023
Session-4: Industry Updates Chair: Cartikeya Reddy
Indian Time	Title	Speaker Name
1.00 to 1:15 PM	Cell therapy solutions for every step – from discovery to cure	Prathap Naidu Thermo Fisher Scientific, Mumbai, India
1:15 to 1:30 PM	Presentation on CGT product line of Akadeum Lifescience ,Arcticzymes Technology and BPS Bioscience	Mustansyrr Bohri Inveniolife Technology Pvt. Ltd. Mumbai, India
1:30 to 1:45 PM	Enabling Cell & Gene Therapies from Concept to Patient	Gabriel GATA Lonza India Pvt Ltd., Gurugram, India
1:45 to 2:00 PM	Break
Session-5: IMMUNE CELL THERAPY Chair: Navin Khattry
Indian Time	Title	Speaker Name
2:00 to 2:30 PM	CAR T cell therapy in relapsed/ refractory B cell malignancies- First Industry sponsored trial from India	Sharat Damodar Mazumdar Shaw Medical Centre, Narayana Health City, Bangalore, India
2:30 to 3:00 PM	Manufacturing and clinical testing of allogeneic gamma delta T cells for neuroblastoma and genetic engineering strategies to enhance their anti-cancer effectiveness	H. Trent Spencer Emory University School of Medicine, Atlanta, USA
3:00 to 3:30 PM	Chimeric Antigen Receptor –T cells (CAR-T) therapy for hematological malignancies: The Sheba Experience	Arnon Nagler Chaim Sheba Medical Center, Tel-Hashomer, Israel
3:30 to 3:45 PM	Break
Session-6: APPLICATIONS OF iPSC TECHNOLOGY Chair- Maneesha S. Inamdar Co-chair: Dhandapani Perundurai
Indian Time	Title	Speaker Name
3:45 to 4:15 PM	iPSC-based disease modelling of haematological diseases	R V Shaji Centre for Stem Cell Research (A unit of inStem, Bengaluru) and CMC, Vellore, India
4:15 to 4:45 PM	Quality control for human stem cell lines for clinical application	Glyn Stacey International Stem Cell Banking, Initiative, UK
4:45 to 5:15 PM	Modelling human neurodevelopmental disorders using iPSC technology	Raghu Padinjat National Centre for Biological Sciences, Bangalore, India
5:15 to 6:00 PM	Poster presentation and Industry Exhibition

Session-7: TECHNOLOGY ADVANCES Chair- Srujan Kumar Marepally
Indian Time	Title	Speaker Name
6:00 to 6:30 PM	HIV gene therapy: A time to prevent, a time to silence, and finally, the time to cure	Priti Kumar Yale University, New Haven, US
6:30 to 7:00 PM	Improving access to ATMPs in India through robust industrial operations	Giridhar K Chenji Immuneel Therapeutics Private Limited, Bangalore, India
7:00 to 7:30 PM	In vivo HSC gene editing for hemoglobinopathies	Chang Li University of Washington, Seattle, WA
7:30 to 8:00 PM	The quest for next generation lipid nanoparticles for cell-specific delivery of mRNA	Gaurav Sahay Oregon State University, Oregon, US
KEYNOTE ADDRESS Chair: Mammen Chandy
Indian Time	Title	Speaker Name
8:00 to 9:00 PM	Clinical Cardiac Gene Therapy Comes of Age	Roger Hajjar Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, USA
End of Day-2

DAY-3: Saturday, 2^ndSEPTEMBER, 2023
Session-8: GENE EDITING Chair: Souvik Maiti
Indian Time	Title	Speaker Name
2:00 to 2:30 PM	Bi-functional gene editing of the Hematopoietic Stem and Progenitor Cells for β-hemoglobinopathies gene therapy	Saravanabhavan Thangavel Centre for Stem Cell Research (A unit of inStem, Bengaluru), Vellore, India
2:30 to 3:00 PM	Targeted genome-engineering of hematopoietic stem progenitor cells for reactivation of fetal hemoglobin	Sivaprakash Ramalingam CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi, India
3:00 to 3:30 PM	Precision genome editing for beta-hemoglobinopathies	Mohankumar Murugesan Centre for Stem Cell Research (A unit of inStem, Bengaluru), Vellore, India
3:30 to 3:45 PM	Break
3:45 to 4:30 PM	Poster presentation and Industry Exhibition
Session-9: GENE THERAPY Chair: R V Shaji
Indian Time	Title	Speaker Name
4:30 to 5:00 PM	Development of genome-modified generation Z (GenZ) single-stranded AAV vectors with improved transgene expression	Arun Srivastava University of Florida, Florida, USA
5:00 to 5:30 PM	AAV Dual Vector Designs for Therapeutic Applications	Arkasubhra Ghosh Narayana Nethralaya Foundation, Bengaluru, India
5:30 to 6:00 PM	Complexity of Cellular Immune Responses in The Liver	Roland W. Herzog Indiana University, Indianapolis, USA
End of Day-3