Centre for Stem Cell Research

This program is coordinated by Vrisha Madhuri with her team. The major focus is on clinical translations related to physis, articular cartilage and bone regeneration. For articular cartilage regeneration, ongoing small and large animal studies have articular defect reconstruction with differentiated MSCs on indigenous scaffolds. The continued follow up for human physeal regeneration with culture expanded autologous chondrocytes has shown success at 2.5 years follow-up and work is ongoing for similar physeal regeneration using 3D scaffolds in large animals. In a first of its kind study, reconstructions of bone defects in children with MSCs differentiated to osteoblasts on ceramic scaffolds have shown good outcome in the first 5 cases. A larger trial is being planned.